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Volume 20, Number 5—May 2014


Human Papillomavirus Prevalence in Oropharyngeal Cancer before Vaccine Introduction, United States

Martin SteinauComments to Author , Mona Saraiya, Marc T. Goodman, Edward S. Peters, Meg Watson, Jennifer L. Cleveland, Charles F. Lynch, Edward J. Wilkinson, Brenda Y. Hernandez, Glen Copeland, Maria S. Saber, Claudia Hopenhayn, Youjie Huang, Wendy Cozen, Christopher Lyu, Elizabeth R. Unger, and the HPV Typing of Cancers Workgroup
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (M. Steinau, M. Saraiya, M. Watson, J.L. Cleveland, E.R. Unger); Cedars-Sinai Medical Center, Los Angeles, California, USA (M.T. Goodman); Louisiana State University, New Orleans, Louisiana, USA (E.S. Peters); University of Iowa, Iowa City, Iowa, USA (C.F. Lynch); University of Florida, Gainesville, Florida, USA (E.J. Wilkinson); University of Hawaii, Honolulu, Hawaii, USA (B.Y. Hernandez); Michigan Cancer Surveillance Program, Lansing, Michigan, USA (G. Copeland); Los Angeles Cancer Registry, Los Angeles, California, USA (M.S. Saber, W. Cozen); University of Kentucky, Lexington, Kentucky, USA (C. Hopenhayn); Florida Department of Health, Tallahassee, Florida, USA (Y. Huang); Battelle Memorial Institute, Durham, North Carolina, USA (C. Lyu)

Main Article

Table 3

Human papillomavirus prevalence in oropharyngeal squamous cell carcinomas, select United States registries, 1995–2005*

Variable   No. (%) cases, N = 557
HPV (any type) 403 (72.4)
High risk† 396 (71.1)
Low risk‡ 7 (1.3)
Negative 154 (27.6)
Single type 381 (68.4)
Multiple types§
22 (3.9)
HPV-16 337 (60.5)
HPV-33 31 (5.6)
HPV-18 14 (2.5)
HPV-35 11 (2.0)
HPV-39 5 (0.9)
HPV-31 4 (0.7)
HPV-52 4 (0.7)
HPV-45 3 (0.5)
Other HPV types 16 (2.9)

*HPV, human papillomavirus; high risk, virus type is associated with high oncogenic potential; low risk, virus type is associated with low oncogenic potential.
†Positive for any of HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68.
‡Positive for types other than those identified as high risk.
§HPV-16/-33 (6 cases), HPV-16/-18 (3 cases), and HPV-16/-31(3 cases).

Main Article

1Members of HPV Typing of Cancers Workgroup who contributed to this study are listed at the end of this article.