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Volume 20, Number 7—July 2014
Dispatch

Diversity of Francisella tularensis Subsp. holarctica Lineages, China

Yanhua Wang, Yao Peng, Rong HaiComments to Author , Lianxu Xia, Hang Li, Zhikai Zhang, Hong Cai, Ying Liang, Xiaona Shen, Dongzheng Yu, Dawn Birdsell, David M. Wagner, and Paul KeimComments to Author 
Author affiliations: National Institute for Communicable Disease Control and Prevention; State Key Laboratory for Infectious Disease Prevention and Control; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China (Y. Wang, Y. Peng, R. Hai, L. Xia, Z. Zhang, H. Cai, Y. Liang, X. Shen, D. Yu); Beijing Genomics Institute–Shenzhen, Shenzhen, China (H. Li); Northern Arizona University, Flagstaff, Arizona, USA (D. Birdsell, D.M. Wagner, P. Keim)

Main Article

Table 1

Francisella tularensis isolates used in study of lineages in China*

Strain ID Year of isolation Region and country Subspecies or species Source F.3 910179† B.2 5162‡ B.3 470841‡ B.4 823672‡ B.5 1853655‡ B.6 713647‡ B.12 109781‡ B.16 608245§ B.17 1743207§ B.19 1373999§ B.20 1396082, 1789417§ B.23 253120§ Major subgroup¶ Subgroup#
410108 1962 Tibet, China subsp. holarctica Human G C G A C G A T C C T C BV B.16
410109 1962 Tibet, China subsp. holarctica Human G C G A C G A T C C T C BV B.16
410111 1964 Tibet, China subsp. holarctica Tick (D. everestianus) G C G A C G A T C C T C BV B.16
FSC022** 1950 Japan subsp. holarctica Human G C G A C G A T C C T C BV B.16
410107 Pre-1992 Heilongjiang, China subsp. holarctica Hare G A A A T G T G C A C C BI B.20
410116 1983 Xinjiang, China subsp. holarctica Tick G A A A T G T G C A C C BI B.20
410117 Pre-1992 Xinjiang, China subsp. holarctica Tick G A A A T G T G C A C C BI B.20
FSC200** 1998 Sweden subsp. holarctica Human G A A A T G T G C A C C BI B.20
RC503/ FSC257** 1949 Russia subsp. holarctica Tick (D. pictus) G A A A T G T G C A T A BIII B.23
LVS** UNK Russia subsp. holarctica UNK G A A A T G T G C A T A BIII B.23
410112 1971 Tibet, China subsp. holarctica Tick (D. everestianus) G A A T C G A G A C T C BII B.4
410113 1964 Tibet, China subsp. holarctica Tick (D. everestianus) G A A T C G A G A C T C BII B.4
920607 Pre-1992 Tibet, China subsp. holarctica UNK G A A T C G A G A C T C BII B.4
OSU18** 1978 Oklahoma, United States subsp. holarctica Beaver G A A T C G A G A C T C BII B.4
MI00-1730** 2000 Michigan, United States subsp. holarctica Human G A A T C G A G A C T C BII B.4
410105 1962 Tibet, China subsp. holarctica Human G A A A T A A G C C T C BIV B.6
FTNF002-00** UNK France subsp. holarctica UNK G A A A T A A G C C T C BIV B.6
URFT1** 1997 France subsp. holarctica Human G A A A T A A G C C T C BIV B.6
F92** 2004 Germany subsp. holarctica Marmoset G A A A T A A G C C T C BIV B.6
OR96-0246** 1996 Oregon, United States subsp. holarctica UNK G A A A T A A G C C T C BIV B.6
Schu S4** 1941 Ohio, United States subsp. tularensis Human A C G A C G A G C C T C NA NA
FSC147** 1965 Kazakhstan subsp. mediasiatica Gerbil A C G A C G A G C C T C NA NA
U112** 1950 Utah, United States F. novicida Water A C G A C G A G C C T C NA NA

*Clade designations are underlined. Gray shading indicates derived SNPs; other SNPs are ancestral. ID, Identification; UNK, unknown; NA, not applicable; SNP, single-nucleotide polymorphism.
†SNP from (10). SNP position based on the reference Schu S4 (NC_006570)  
‡Canonical SNP from (7). SNP position based on the reference Schu S4 (NC_006570).
§Canonical SNP from (6), SNP position based on the reference Schu S4 (NC_006570).
¶Major subgroup based on (6).
#Subgroup based on (6,7).
**Reference strain genome published in the National Center for Biotechnology Information (www.ncbi.nlm.nih.gov/genome/genomes/511).

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