Epidemiology, Clinical Manifestations, and Outcomes of Streptococcus suis Infection in Humans
Vu Thi Lan Huong
1, Ngo Ha
1, Nguyen Tien Huy
1, Peter Horby, Ho Dang Trung Nghia, Vu Dinh Thiem, Xiaotong Zhu, Ngo Thi Hoa, Tran Tinh Hien, Javier Zamora, Constance Schultsz, Heiman Frank Louis Wertheim, and Kenji Hirayama
Author affiliations: Oxford University Clinical Research Unit, Hanoi, Vietnam (V.T.L. Huong, P. Horby, H.F.L. Wertheim); University of Oxford, Oxford, UK (V.T.L. Huong, P. Horby, H.F.L. Wertheim, N.T. Hoa); Nagasaki University, Nagasaki, Japan (N. Ha, N.T. Huy, X. Zhu, K. Hirayama); Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam (H.D.T. Nghia, N.T. Hoa, T.T. Hien, C. Schultsz); National Institute of Hygiene and Epidemiology, Hanoi (V.D. Thiem); Ramón y Cajal Hospital, Madrid, Spain (J. Zamora); CIBER Epidemiologia y Salud Publica, Madrid (J. Zamora); Pham Ngoc Thach University of Medicine, Ho Chi Minh City (H.D.T. Nghia); University of Amsterdam, Amsterdam, the Netherlands (C. Schultsz)
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Figure 3
Figure 3. Funnel plot showing evidence of publication bias among 26 studies in a meta-analysis of meningitis rates in Streptococcus suis infectionEach blue circle represents each study in the meta-analysis, forming an asymmetric funnel plot with a pooled log event rate (blue rhombus)Eight missing studies (red circles) added in the left side through the trim and fill method to make the plot more symmetric and gave an adjusted log event rate (red rhombus), which was lower than the original one.
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