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Volume 20, Number 7—July 2014

Epidemiology, Clinical Manifestations, and Outcomes of Streptococcus suis Infection in Humans

Vu Thi Lan Huong1, Ngo Ha1, Nguyen Tien Huy1, Peter Horby, Ho Dang Trung Nghia, Vu Dinh Thiem, Xiaotong Zhu, Ngo Thi Hoa, Tran Tinh Hien, Javier Zamora, Constance Schultsz, Heiman Frank Louis Wertheim, and Kenji HirayamaComments to Author 
Author affiliations: Oxford University Clinical Research Unit, Hanoi, Vietnam (V.T.L. Huong, P. Horby, H.F.L. Wertheim); University of Oxford, Oxford, UK (V.T.L. Huong, P. Horby, H.F.L. Wertheim, N.T. Hoa); Nagasaki University, Nagasaki, Japan (N. Ha, N.T. Huy, X. Zhu, K. Hirayama); Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam (H.D.T. Nghia, N.T. Hoa, T.T. Hien, C. Schultsz); National Institute of Hygiene and Epidemiology, Hanoi (V.D. Thiem); Ramón y Cajal Hospital, Madrid, Spain (J. Zamora); CIBER Epidemiologia y Salud Publica, Madrid (J. Zamora); Pham Ngoc Thach University of Medicine, Ho Chi Minh City (H.D.T. Nghia); University of Amsterdam, Amsterdam, the Netherlands (C. Schultsz)

Main Article

Table 4

Summary rates of the main clinical outcomes among patients with Streptococcus suis infection included in a systematic review

Variable Single-case dataset, n = 174 Large studies, median (range) Meta-analysis, pooled mean (95% CI) No. studies meta-analyzed*
Death 10.3 8.9 (0.0–56.0) 12.8 (9.0–18.0) 25
Hearing loss† 44.8 38.7 (6.0–100) 39.1 (31.0–47.8) 26
Recovery from hearing loss 5.0 (0.0–52.3) 15.4 (5.3–37.3) 8
Vestibular dysfunction§ 16.7 25.0 (3.3–60.0) 22.7 (15.6–32.0) 13
Visual impairment 4.0 –¶

*Includes the single-case dataset and the large studies (Technical Appendix Table 2).
†Studies included if case-patients were reported to have any degree of hearing impairment (unilateral or bilateral, temporary or permanent).
‡Reliable data could not be extracted for the majority of the case reports.
§Studies included if case-patients were reported to have ataxia, vertigo, loss of balance, or vestibular dysfunction.
¶Dashes indicate not applicable because no large study reported these data.

Main Article

1These authors contributed equally to this article.

Page created: June 17, 2014
Page updated: June 17, 2014
Page reviewed: June 17, 2014
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