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Volume 20, Number 7—July 2014
Research

Independent Lineages of Highly Sulfadoxine-Resistant Plasmodium falciparum Haplotypes, Eastern Africa

Steve M. TaylorComments to Author , Alejandro L. Antonia1, Whitney E. Harrington, Morgan M. Goheen, Victor Mwapasa, Ebbie Chaluluka, Michal Fried, Edward Kabyemela, Mwayi Madanitsa, Carole Khairallah, Linda Kalilani-Phiri, Antoinette K. Tshefu, Stephen J. Rogerson, Feiko O. ter Kuile, Patrick E. Duffy, and Steven R. Meshnick
Author affiliations: Author affiliations: Duke University Medical Center, Durham, North Carolina, USA (S.M. Taylor); University of North Carolina, Chapel Hill, North Carolina, USA (S.M. Taylor, A.L. Antonia, M.M. Goheen, S.R. Meshnick); Seattle Children’s Hospital/University of Washington School of Medicine, Seattle, Washington, USA (W.E. Harrington); College of Medicine, Blantyre, Malawi (V. Mwapasa, E. Chaluluka, M. Madanitsa, L. Kalilani-Phiri); National Institutes of Health, Bethesda, Maryland, USA (M. Fried. P.E. Duffy); Seattle Biomedical Research Institute, Seattle (E. Kabyemela); Liverpool School of Tropical Medicine, Liverpool, UK (C. Khairallah, F.O. ter Kuile); University of Kinshasa, Kinshasha, Democratic Republic of the Congo (A.K. Tshefu); University of Melbourne, Melbourne, Victoria, Australia (S.J. Rogerson); University of Amsterdam, Amsterdam, the Netherlands (F.O. ter Kuile)

Main Article

Figure 1

Genetic relatedness of Plasmodium falciparum dihydropteroate synthase (dhps) haplotypes from Malawi over time based on median-joining network of microsatellite profiles. Median joining network was calculated based on microsatellite profiles for 91 parasites with full genotype data. Colors indicate year and dhps haplotype, nodes are proportional to the number of parasites with that microsatellite profile, red nodes are hypothetical profiles inserted by the program to calculate a parsimonious netw

Figure 1. Genetic relatedness of Plasmodium falciparum dihydropteroate synthase (dhps) haplotypes from Malawi over time based on median-joining network of microsatellite profilesMedian-joining network was calculated based on microsatellite profiles for 91 parasites with full genotype dataColors indicate year and dhps haplotype, nodes are proportional to the number of parasites with that microsatellite profile, red nodes are hypothetical profiles inserted by the program to calculate a parsimonious network, and branch lengths are arbitraryValues were computed in NETWORK v4.6.1.1(24,25)The dhps haplotypes are defined by amino acids at codons 436, 437, 540, and 581Mutant amino acids are underlined and in boldSAKA, wild-type; SGEA and SGEG, mutants.

Main Article

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1Current affiliation: Duke University School of Medicine, Durham, North Carolina, USA.

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Page updated: June 17, 2014
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