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Volume 20, Number 8—August 2014
Research

Independent Origin of Plasmodium falciparum Antifolate Super-Resistance, Uganda, Tanzania, and Ethiopia

Michael Alifrangis1, Sidsel Nag1Comments to Author , Mette L. Schousboe, Deus S. Ishengoma, John Lusingu, Hirva Pota, Reginald A. Kavishe, Richard Pearce, Rosalynn Ord, Caroline Lynch, Seyoum Dejene, Jonathan Cox, John Rwakimari, Daniel T.R. Minja, Martha M. Lemnge, and Cally Roper
Author affiliations: Centre for Medical Parasitology at Department of International Health, Immunology, and Microbiology, Faculty of Health and Medical Science, University of Copenhagen and at Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet),; Copenhagen, Denmark (M. Alifrangis, S. Nag, M.L. Schousboe); Tanga Research Centre, Tanzania (D. Ishengoma, J. Lusingu, D.T.R. Minja, M.M. Lemnge); London School of Hygiene and Tropical Medicine, London, UK (H. Pota, R. Pearce, R. Ord, C. Lynch, J. Cox, C. Roper); Kilimanjaro Christian Medical University College, Moshi, Tanzania (R.A. Kavishe); Kilimanjaro Clinical Research Institute, Moshi (R.A. Kavishe); Médécins Sans Frontières, Humera, Ethiopia (S. Dejene); Ministry of Health of Uganda, Kampala, Uganda (J. Rwakimari)

Main Article

Table

Study sites and number of samples genotyped for super-resistant Plasmodium falciparum, eastern Africa

Study site. SGEAA
 SGEGA
 Total haplotype diversity
No. samples Haplotype diversity No. samples Haplotype diversity
Ethiopia, Humera, Tigray 35 4 41 1 4
Uganda
Bufundi, Kabale 24 5 14 3 7
Kebisoni, Rukungiri 27 5 14 3 7
Tanzania
Hale, Tanga 21 6 15 3 8
Korogwe, Tanga 64 21 19 3 22
Magoda, Tanga 7 3 15 6 6

*By country, district, village. Samples from Ethiopia are from 2004; samples from Uganda are from 2005; and samples from Tanzania are from 2004 (Korogwe only), 2006 (Korogwe and Hale), 2007 (Korogwe only) and 2008 (Magoda only).

Main Article

1These authors contributed equally to this article.

Page created: July 18, 2014
Page updated: July 18, 2014
Page reviewed: July 18, 2014
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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