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Volume 20, Number 9—September 2014

CME ACTIVITY - Research

Pneumocystis jirovecii Pneumonia in Patients with or without AIDS, France

Antoine Roux, Emmanuel Canet, Sandrine Valade, Florence Gangneux-Robert, Samia Hamane, Ariane Lafabrie, Daniéle Maubon, Anne Debourgogne, Soléne Le Gal, Fréderic Dalle, Marion Leterrier, Dominique Toubas, Christelle Pomares, Anne Pauline Bellanger, Julie Bonhomme, Antoine Berry, Isabelle Durand-Joly, Denis Magne, Denis Pons, Christophe Hennequin, Eric Maury, Patricia Roux1, and Élie AzoulayComments to Author 
Author affiliations: Centre Medico-Chirurgical FOCH, Suresnes, France (A. Roux); Hôpital Saint-Louis, Paris, France (E. Canet, S. Valade, S. Hamane, A. Lafabrie, É. Azoulay); Centre Hospitalier Universitaire (CHU) de Rennes, Rennes, France (F. Gangneux-Robert ); CHU de Grenoble, Grenoble, France (D. Maubon); CHU de Nancy, Nancy, France (A. Debourgogne); Centre Hospitalier Régional et Universitaire de Brest, Brest, France (S. Le Gal); CHU de Dijon, Dijon, France (F. Dalle); CHU de Nantes, Nantes, France (M. Leterrier); CHU de Reims, Reims, France (D. Toubas); Hôpital de l’Archet, Nice, France (C. Pomares); CHU Jean Minjoz, Besançon, France (A.P. Bellanger); CHU Côte de Nacre, Caen, France (J. Bonhomme); CHU de Toulouse, Toulouse, France (A. Berry); CHU de Lille, Lille, France (I. Durand-Joly); Hôpital Saint-Antoine, Paris (D. Magne, C. Hennequin, P. Roux, E. Maury); CHU Gabriel Montpied, Clermont-Ferrand, France (D. Pons)

Main Article

Table 3

Multivariate analysis of independent predictors of hospital death for AIDS and non-AIDS patients with PCP, France, January 1, 2007–December 31, 2010*

Variable Odds ratio (95% CI)
HIV infection 0.33 (0.12–0.92)
Solid organ transplant 0.08 (0.02–0.31)
Age, per additional year 1.04 (1.02–1.06)
Allogeneic HSCT 8.6 (1.40–53.02)
Need for immediate oxygen therapy 4.06 (1.44–11.5)
Need for intubation and mechanical ventilation 16.70 (7.25–38.47)
Time to PCP treatment, per additional day 1.11 (1.04–1.18)

*Variables from Tables 1 and 2 were introduced into the multivariate model based on their association with hospital mortality by bivariate analysis with p values <0.20. Higher numbers indicate increased odds, with 1 as the cutoff point (i.e., values <1.00 indicate decreased risk, >1.00 increased risk). Goodness of fit (Hosmer-Lemeshow test) was 0.61. PCP, Pneumocystis jirovecii pneumonia; HSCT, hematopoietic stem cell transplant.

Main Article

1Deceased.

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