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Volume 21, Number 1—January 2015
Online Report

Workshop on Use of Intravenous Immunoglobulin in Hand, Foot and Mouth Disease in Southeast Asia

Sokkosal Chea, Yi-bing Cheng, Kulkanya Chokephaibulkit, Tawee Chotpitayasunondh, H. Rogier van DoornComments to Author , Zen Hafy, Surinda Kawichai, Ching-Chuan Liu, Nguyen Tran Nam, Mong How Ooi, Marcel Wolbers, and Mei Zeng
Author affiliations: Angkor Hospital for Children, Siem Reap, Cambodia (S. Chea); Zhenzhou Children’s Hospital, Henan, China (Y. Cheng); Siriraj Hospital, Mahidol University, Bangkok, Thailand (K. Chokephaibulkit); Queen Sirikit National Institute of Child Health, Bangkok (T. Chotpitayasunondh); Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam (H.R. van Doorn, M. Wolbers); Family Health International 360, Bangkok (Z. Hafy, S. Kawichai); National Cheng Kung University, Tainan, Taiwan (C.-C. Liu); Children’s Hospital 2, Ho Chi Minh City (N.T. Nam); Sarawak General Hospital, Kuching, Sarawak, Malaysia (M.H. Ooi); Fudan University Children’s Hospital, Shanghai, China (M. Zeng)

Main Article

Table 1

Total required sample size for a 1:1 randomized trial designed to demonstrate superiority of IVIg compared with placebo at the 2-sided 5% significance level with 90% power*

Absolute risk of progression, IVIg group Absolute risk increase for placebo group compared with IVIg
+5% +7.5% +10% +15%
15% 2,424 1,136 670 322
20% 2,928 1,350 784 370

*Sample sizes are total sample sizes (i.e., for both groups combined) but do not account for loss-to-follow-up or increases in sample size that would be required if formal interim analyses with stopping boundaries are planned. IVIg, intravenous immunoglobulin.

Main Article

Page created: December 10, 2014
Page updated: December 10, 2014
Page reviewed: December 10, 2014
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