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Volume 21, Number 10—October 2015
Research

Induction of Multidrug Tolerance in Plasmodium falciparum by Extended Artemisinin Pressure

Sandie Ménard, Tanila Ben Haddou, Arba Pramundita Ramadani1, Frédéric Ariey, Xavier Iriart, Johann Beghain, Christiane Bouchier, Benoit Witkowski2, Antoine Berry, Odile Mercereau-Puijalon, and Françoise Benoit-VicalComments to Author 
Author affiliations: Université de Toulouse, Toulouse, France (S. Ménard, T. Ben Haddou, A.P. Ramadani, X. Iriart, B. Witkowski, A. Berry, F. Benoit-Vical); Centre de Physiopathologie de Toulouse-Purpan, Toulouse (S. Ménard. X. Iriart, A. Berry); Laboratoire de Chimie de Coordination du Centre National de la Recherche Scientifique, Toulouse (T. Ben Haddou, A.P. Ramadani, B. Witkowski, F. Benoit-Vical); Institut Pasteur, Paris, France (F. Ariey, J. Beghain, C. Bouchier, O. Mercereau-Puijalon); Centre Hospitalier Universitaire de Toulouse, Toulouse (X. Iriart, A. Berry)

Main Article

Figure 1

In vitro drug survival assays for Plasmodium falciparum. Representative curves for kinetic recrudescence of synchronous ring-stage parasites from F32-ART5 lineage (dashed lines) and F32-TEM lineage (solid lines) parasite cultures after a 48-h exposure to A) 11 μmol/L artemisinin; B) 62 nmol/L amodiaquine; C) 241 nmol/L mefloquine; D) 4 μmol/L pyrimethamine; and E) 7 μmol/L atovaquone. Differences in recrudescence between both parasite lines are indicated by doubled-headed arrows.

Figure 1. In vitro drug survival assays for Plasmodium falciparum. Representative curves for kinetic recrudescence of synchronous ring-stage parasites from F32-ART5 lineage (dashed lines) and F32-TEM lineage (solid lines) parasite cultures after a 48-h exposure to A) 11 μmol/L artemisinin; B) 62 nmol/L amodiaquine; C) 241 nmol/L mefloquine; D) 4 μmol/L pyrimethamine; and E) 7 μmol/L atovaquone. Differences in recrudescence between both parasite lines are indicated by doubled-headed arrows.

Main Article

1Current affiliation: Universitas Gadjah Mada, Yogyakarta, Indonesia.

2Current affiliation: Institut Pasteur, Phnom Penh, Cambodia.

Page created: September 22, 2015
Page updated: September 22, 2015
Page reviewed: September 22, 2015
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