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Volume 21, Number 2—February 2015
Research

Simulation Study of the Effect of Influenza and Influenza Vaccination on Risk of Acquiring Guillain-Barré Syndrome

Steven Hawken, Jeffrey C. Kwong, Shelley L. Deeks, Natasha S. Crowcroft, Allison McGeer, Robin Ducharme, Michael A. Campitelli, Doug Coyle, and Kumanan WilsonComments to Author 
Author affiliations: Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada (S. Hawken, J.C. Kwong, R. Ducharme, M.A. Campitelli, K. Wilson); Ottawa Hospital Research Institute, Ottawa, Ontario, Canada (S. Hawken, R. Ducharme, K. Wilson); University of Ottawa, Ottawa (S. Hawken, D. Coyle, K. Wilson); Public Health Ontario, Toronto (J.C. Kwong, S.L. Deeks, N.S. Crowcroft); Dalla Lana School of Public Health, University of Toronto, Toronto (J.C. Kwong, S.L. Deeks, N.S. Crowcroft, A.J. McGeer); University of Toronto, Toronto (J.C. Kwong, N.S. Crowcroft, A.J. McGeer)

Main Article

Figure 2

Sensitivity analyses for the excess risk of Guillain-Barré syndrome (GBS) per 1,000,000 influenza vaccinations. A) 45-year-old woman, assuming a 10% influenza incidence rate, 61% vaccine effectiveness, and combined relative risk (RR) of GBS of 17.33. B) 75-year-old man, assuming a 10% influenza incidence rate, vaccine effectiveness of 50% and combined RR of GBS of 17.33. Depending on the joint distribution of the probabilistic inputs to the simulation, these deterministic sensitivity analyses wi

Figure 2. Sensitivity analyses for the excess risk of Guillain-Barré syndrome (GBS) per 1,000,000 influenza vaccinations. A) 45-year-old woman, assuming a 10% influenza incidence rate, 61% vaccine effectiveness, and combined relative risk (RR) of GBS of 17.33. B) 75-year-old man, assuming a 10% influenza incidence rate, vaccine effectiveness of 50% and combined RR of GBS of 17.33. Depending on the joint distribution of the probabilistic inputs to the simulation, these deterministic sensitivity analyses will not necessarily yield identical mean/median estimates to those from the probabilistic simulation for the same age, sex, and influenza incidence rate.

Main Article

Page created: January 20, 2015
Page updated: January 20, 2015
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