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Volume 21, Number 3—March 2015
Dispatch

Novel Mutations in K13 Propeller Gene of Artemisinin-Resistant Plasmodium falciparum

Rie IsozumiComments to Author , Haruki Uemura, Isao Kimata, Yoshio Ichinose, John Logedi, Ahmeddin H. Omar, and Akira Kaneko
Author affiliations: Osaka City University, Osaka, Japan (R. Isozumi, I. Kimata, A. Kaneko); Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan (H. Uemura, Y. Ichinose); Ministry of Public Health and Sanitation, Nairobi, Kenya (J. Logedi, A.H. Omar); Karolinska Institutet, Stockholm, Sweden (A. Kaneko)

Main Article

Table 2

Observed mutations in the K13 propeller gene in Plasmodium falciparum, Mbita District, Kenya, 2012–2013

Mutation Amino acid change and location Genetic change Study site (no. isolates)
2012 Feb 2012 Aug 2013 Aug
Nonsynonymous
 M442V ATG →GTG Mfangano (1)
N554S AAT →AGT Ungoye (1)
A569S GCA →TCA Ungoye (1)
A578S
 GCT →TCT
 Mfangano (4)
 Mfangano (1)
Synonymous C439C TGC→TGT Ungoye (2)
S477S TCT →TCG Takawiri (1)
Y500Y TAT→TAC Mfangano (1)
N531N AAT →AAC Ungoye (1)
G538G GGT→GGA Mfangano (3)

Main Article

Page created: February 18, 2015
Page updated: February 18, 2015
Page reviewed: February 18, 2015
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