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Volume 21, Number 3—March 2015

Dispatch

Rapid Detection of ESBL-Producing Enterobacteriaceae in Blood Cultures

Laurent Dortet, Laurent Poirel, and Patrice NordmannComments to Author 
Author affiliations: Institut National de la Santé et de la Recherche Médicale, Le Kremlin–Bicêtre, France (L. Dortet, L. Poirel, P. Nordmann); University of Fribourg, Fribourg, Switzerland, Department of Medicine (L. Poirel, P. Nordmann); Hôpital Fribourgeois-hôpital Cantonal, Fribourg (P. Nordmann)

Main Article

Table 3

MC values of several β-lactams and β-lactamase content for the extended-spectrum b-lactamase –producing Enterobacteriaceae in blood cultures*

Hospitalization unit a Species MICs (μg/mL)†
 β-Lactamase content c
CAZ CTX FEP CAZ/TZB CTX/TZB FEP/TZB SHV TEM CTX-M
Emergency Escherichia coli 2† 8 2 0.19 0.032 0.023 – – CTX-M-1
Rhumatology E. coli 1 12 2 0.19 0.032 0.016 – TEM-1 CTX-M-1
Emergency E. coli 32 48 8 0.75 0.25 0.064 SHV-12‡ – CTX-M-3
Emergency E. coli 1.5 16 6 0.38 0.094 0.064 – TEM-1 CTX-M-14
ICU E. coli 1 16 3 0.19 0.016 0.023 – TEM-1 CTX-M-14
Nephrology E. coli 0.5 12 1.5 0.094 0.047 0.016 – TEM-1 CTX-M-14
Nephrology E. coli 0.38 8 1.5 0.125 0.032 0.023 – TEM-1 CTX-M-14
Surgery E. coli 0.5 12 2 0.19 0.032 0.032 – TEM-1 CTX-M-14
ICU E. coli 8 96 6 0.19 0.032 0.032 – – CTX-M-15
ICU E. coli 1 16 0.75 0.094 0.032 0.047 – – CTX-M-15
Infectious diseases E. coli 12 128 12 0.25 0.094 0.064 – – CTX-M-15
Infectious diseases E. coli 16 128 12 0.19 0.094 0.094 – – CTX-M-15
Surgery E. coli 12 128 12 0.38 0.5 2 – – CTX-M-15
Urology E. coli 16 192 16 0.25 0.19 0.064 – TEM-1 CTX-M-15
Urology E. coli 12 192 8 0.25 0.125 0.064 – TEM-1 CTX-M-15
Infectious diseases E. coli 32 128 16 0.19 0.047 0.064 – TEM-1 CTX-M-15
Nephrology E. coli 48 6 1 0.38 0.19 0.094 SHV-12 TEM-1 –
Nephrology E. coli 48 6 1 0.38 0.19 0.094 SHV-12 TEM-1 –
Infectious diseases E. coli 12 128 8 0.19 0.047 0.023 – – CTX-M-15
Nephrology E. coli 16 128 12 0.25 0.094 0.047 – – CTX-M-15
ICU E. coli 256 256 192 32 24 2 – – CTX-M-15
ICU E. coli 8 96 6 0.19 0.064 0.064 – – CTX-M-15
ICU E. coli 12 128 6 0.125 0.064 0.125 – – CTX-M-15
Infectious diseases E. coli 32 256 24 0.5 0.19 0.094 – – CTX-M-15
Infectious diseases E. coli 32 256 24 0.5 0.19 0.094 – – CTX-M-15
Infectious diseases E. coli 256 256 16 0.5 0.016 0.094 – – CTX-M-15
Pneumology E. coli 32 256 16 0.5 0.094 0.032 – TEM-1 CTX-M-15
Emergency E. coli 256 12 1 0.094 0.032 0.016 – – CTX-M-27
ICU E. coli 1 12 1 0.094 0.023 0.023 – – CTX-M-27
Nephrology
 E. coli
 2
 2
 1.5
 0.094
 0.016
 0.016
–
 TEM-1
 CTX-M-55
ICU Klebsiella pneumoniae 3 32 4 0.125 0.023 0.032 – TEM-1 CTX-M-15
Infectious diseases K. pneumoniae 32 256 8 0.38 0.125 0.094 – TEM-1 CTX-M-15
ICU K. pneumoniae 128 256 64 1 0.25 0.19 LEN-5 – CTX-M-15
ICU K. pneumoniae 256 256 32 2 0.5 2 LEN-5 TEM-1 CTX-M-15
Nephrology K. pneumoniae 16 128 6 0.25 0.064 0.047 SHV-1 TEM-1 CTX-M-15
Hepatology K. pneumoniae 6 96 6 0.19 0.047 0.19 SHV-1 TEM-1 CTX-M-15
Nephrology K. pneumoniae 8 96 4 0.25 0.064 0.032 SHV-1 TEM-1 CTX-M-15
ICU K. pneumoniae 48 256 24 0.5 0.064 0.064 SHV-1 TEM-1 CTX-M-15
Hepatology K. pneumoniae 16 64 6 0.5 0.25 0.125 SHV-11 TEM-1 CTX-M-15
Hepatology K. pneumoniae 12 48 6 0.5 0.19 0.094 SHV-11 TEM-1 CTX-M-15
ICU K. pneumoniae 12 128 12 0.38 0.047 0.094 SHV-11 TEM-1 CTX-M-15
Nephrology K. pneumoniae 48 256 16 0.5 0.19 0.5 SHV-11 TEM-1 CTX-M-15
ICU
 K. pneumoniae
 256
 256
 24
 0.25
 0.047
 0.064
SHV-28
 TEM-1
 CTX-M-15
ICU Enterobacter cloacae 96 256 32 1 1 0.25 – – CTX-M-15
Nephrology E. cloacae 12 192 12 0.25 0.125 0.047 – TEM-1 CTX-M-15
ICU
 E. cloacae
 12
 128
 6
 0.25
 0.047
 0.047
SHV-1
 TEM-1
 CTX-M-15
Emergency Citrobacter freundii 16 12 2 2 1 0.5 – TEM-3 +TEM-1 CTX-M-55

ICU, intensive care unit, CAZ, ceftazidime; CTX, cefotaxime; FEP, cefepime; TZB, tazobactam; –, negative PCR result.
†Numbers in bold text indicate MIC values reported in the range of susceptibility according to Clinical Laboratory Standards Institute guidelines as updated in 2014 (susceptible means MIC ≤1 μg/mL, ≤4 μg/mL and ≤2 μg/mL for cefotaxime, ceftazidime and cefepime, respectively).
‡Bold, underlined text indicates ESBL names.

Main Article

Page created: February 18, 2015
Page updated: February 18, 2015
Page reviewed: February 18, 2015
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