Volume 21, Number 5—May 2015
Dispatch
Genetic Characterization of Highly Pathogenic Avian Influenza (H5N8) Virus from Domestic Ducks, England, November 2014
Amanda Hanna
, Jill Banks, Denise A. Marston, Richard J. Ellis, Sharon M. Brookes, and Ian H. Brown
, Jill Banks, Denise A. Marston, Richard J. Ellis, Sharon M. Brookes, and Ian H. Brown
Table 2
Genetic mutations identified in highly pathogenic avian influenza (H5N8) virus isolate A/duck/England/36254/2014 that might result in phenotypic consequences, England, 2014*
| Protein, amino acid position/motif | Phenotypic consequences† | |
|---|---|---|
| PB1-F2, | ||
| N66S |
Increased virulence, replication efficiency and antivirus response in mice |
|
| HA | ||
| S133A | Increased psuedovirus binding to α2,6 | |
| T156A | Increased virus binding to α2,6 and increased transmission in guinea pigs | |
| 323–330 (R-X-R/K-R) |
Polybasic cleavage motif sequence required for high pathogenicity |
|
| M1 | ||
| N30D | Increased virulence in mice | |
| T215A |
Increased virulence in mice |
|
| M2 | ||
| S31N |
Reduced susceptibility to amantadine and rimantadine antiviral drugs |
|
| NS1 | ||
| P42S | Increased virulence in mice | |
| I101M | Increased virulence in mice | |
*Phenotypic consequences may include an influence on viral phenotypic characteristics of importance, adaptation to mammalian species, or altered susceptibility to existing antiviral drugs. H5N1 numbering based on the mature HA protein relative to A/Vietnam/1203/2004. PB, polymerase basic protein; HA, hemagglutinin; M, matrix; NS, nonstructural.
†The mutation to the right of the amino acid position confers the phenotypic consequence described.
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