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Volume 21, Number 5—May 2015
CME ACTIVITY - Perspective

Recent US Case of Variant Creutzfeldt-Jakob Disease—Global Implications

Atul MaheshwariComments to Author , Michael Fischer, Pierluigi Gambetti, Alicia Parker, Aarthi Ram, Claudio Soto, Luis Concha-Marambio, Yvonne Cohen, Ermias D. Belay, Ryan A. Maddox, Simon Mead, Clay Goodman, Joseph S. Kass, Lawrence B. Schonberger, and Haitham M. Hussein
Author affiliations: Baylor College of Medicine, Houston, Texas, USA (A. Maheshwari, A. Parker, A. Ram, C. Goodman, J.S. Kass); Harris Health System, Houston (A. Maheshwari, A. Parker, A. Ram, J.S. Kass); Texas Department of State Health Services, Austin, Texas, USA (M. Fischer); Case Western Reserve University School of Medicine, Cleveland, Ohio, USA (P. Gambetti, Y. Cohen); University of Texas Medical School at Houston, Houston (C. Soto, L. Concha-Marambio); Universidad de los Andes, Santiago, Chile (L. Concha-Marambio); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (E.D. Belay, R.A. Maddox, L.B. Schonberger); University College London Institute of Neurology, London, UK (S. Mead); HealthPartners Clinics & Services, St. Paul, Minnesota, USA (H.M. Hussein)

Main Article

Figure 2

Magnetic resonance imaging (MRI) results for a US patient with variant Creutzfeldt-Jakob disease. A) T1 sequence. B) T2 FLAIR sequence showing the “pulvinar” or “hockey stick” sign (arrowhead). Initial Diffusion Weighted Imaging (DWI) (C) and Apparent Diffusion Coefficient (ADC) (D) images show subtle restricted diffusion in right primary motor cortex; subsequent MRIs show increasing hyperintensity on DWI (E,G) and further attenuation on ADC (F,H), consistent with the “cortical ribbon” sign. Ori

Figure 2. Magnetic resonance imaging (MRI) results for a US patient with variant Creutzfeldt-Jakob disease. T1 sequence (A) and T2 FLAIR sequence (B) show the “pulvinar” or “hockey stick” sign (arrowhead). Initial diffusion weighted imaging (DWI) (C) and apparent diffusion coefficient (ADC) (D) images show subtle restricted diffusion in the right primary motor cortex (arrows). Subsequent MRIs show increasing hyperintensity (arrows) on DWI (E, then G) and further attenuation (arrows) on ADC (F, then H), consistent with the “cortical ribbon” sign.

Main Article

Page created: April 19, 2015
Page updated: April 19, 2015
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