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Volume 21, Number 5—May 2015
CME ACTIVITY - Perspective

Recent US Case of Variant Creutzfeldt-Jakob Disease—Global Implications

Atul MaheshwariComments to Author , Michael Fischer, Pierluigi Gambetti, Alicia Parker, Aarthi Ram, Claudio Soto, Luis Concha-Marambio, Yvonne Cohen, Ermias D. Belay, Ryan A. Maddox, Simon Mead, Clay Goodman, Joseph S. Kass, Lawrence B. Schonberger, and Haitham M. Hussein
Author affiliations: Baylor College of Medicine, Houston, Texas, USA (A. Maheshwari, A. Parker, A. Ram, C. Goodman, J.S. Kass); Harris Health System, Houston (A. Maheshwari, A. Parker, A. Ram, J.S. Kass); Texas Department of State Health Services, Austin, Texas, USA (M. Fischer); Case Western Reserve University School of Medicine, Cleveland, Ohio, USA (P. Gambetti, Y. Cohen); University of Texas Medical School at Houston, Houston (C. Soto, L. Concha-Marambio); Universidad de los Andes, Santiago, Chile (L. Concha-Marambio); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (E.D. Belay, R.A. Maddox, L.B. Schonberger); University College London Institute of Neurology, London, UK (S. Mead); HealthPartners Clinics & Services, St. Paul, Minnesota, USA (H.M. Hussein)

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Figure 3

Results of histopathologic and immunohistochemical analyses for a US patient with variant Creutzfeldt-Jakob disease. A) Hematoxylin and eosin staining shows many typical florid plaques (A, arrow) occasionally forming clusters; large vacuole spongiform change is also present (A; original magnification ×10). B) Plaques often not of the florid type along with spongiform change are present in cerebellum (arrows; original magnification ×20). C, D) Prion protein immunostaining confirms the presence of

Figure 3. Results of histopathologic and immunohistochemical analyses for a US patient with variant Creutzfeldt-Jakob disease. A) Hematoxylin and eosin staining shows many typical florid plaques (A, arrow) occasionally forming clusters; large vacuole spongiform change is also present (original magnification ×10). B) Plaques often not of the florid type along with spongiform change are present in cerebellum (arrows; original magnification ×20). C, D) Prion protein immunostaining confirms the presence of PrP in the plaques, which intensely immunostained (C; original magnification ×10), and highlights small round cells surrounded by short processes (D, antibody 3F4; original magnification ×40). E) Under high magnification, a prion plaque with spongiform change is seen in the left frontal cortex (original magnification ×400).

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Page created: April 19, 2015
Page updated: April 19, 2015
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