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Volume 21, Number 6—June 2015

Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus

J.W.M. van der LindenComments to Author , M.C. Arendrup, A. Warris, K. Lagrou, H. Pelloux, P.M. Hauser, E. Chryssanthou, E. Mellado, S.E. Kidd, A.M. Tortorano, E. Dannaoui, P. Gaustad, J.W. Baddley, A. Uekötter, C. Lass-Flörl, N. Klimko, C.B. Moore, D.W. Denning, A.C. Pasqualotto, C. Kibbler, S. Arikan-Akdagli, D. Andes, J. Meletiadis, L. Naumiuk, M. Nucci, W.J.G. Melchers, and P.E. Verweij
Author affiliations: Author affiliations: Radboud University Medical Centre Nijmegen, Nijmegen, the Netherlands (J.W.M. van der Linden, W.J.G. Melchers, P.E. Verweij); Statens Serum Institute, Copenhagen, Denmark (M.C. Arendrup); University of Aberdeen, Aberdeen, UK (A. Warris); Catholic University Leuven, Leuven, Belgium (K. Lagrou); Centre Hospitalier Universitaire, Grenoble, France (H. Pelloux); Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (P.M. Hauser); Karolinska University Hospital Solna, Stockholm, Sweden (E. Chryssanthou); Instituto de Salud Carlos III, Madrid, Spain (E. Mellado); The Alfred Hospital, Melbourne, Victoria, Australia (S.E. Kidd); Università degli Studi di Milano, Milan, Italy (A.M. Tortorano); Hopital Européen G. Pompidou and Université Paris 5, Paris, France (E. Dannaoui); Oslo University Hospital and Rikshospitalet, Oslo, Norway (P. Gaustad); University of Alabama at Birmingham, Birmingham, Alabama, USA (J.W. Baddley); University of Münster, Münster, Germany (A. Uekötter); University of Innsbruck, Innsbruck, Austria (C. Lass-Flörl); North Western State Medical University, Saint Petersburg, Russia (N. Klimko); University of Manchester and Mycology Reference Centre of the University Hospital of South Manchester, Manchester, UK (C.B. Moore, D.W. Denning); Santa Casa de Misericordia de Porto Alegre and Universidade Federal de Ciencias da Saude de Porto Alegre, Porto Alegre, Brazil (A.C. Pasqualotto); Royal Free London NHS Foundation Trust and University College London, London, UK (C. Kibbler); Hacettepe University Medical School, Ankara, Turkey (S. Arikan-Akdagli); University of Wisconsin, Madison, Wisconsin, USA (D. Andes); Attikon University Hospital, Athens, Greece (J. Meletiadis); Hospital of the Medical University of Gdansk, Gdansk, Poland (L. Naumiuk); Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil (M. Nucci)

Main Article

Table 2

Acquired resistance mechanisms from each country in cyp51A gene in 47 Aspergillus fumigatus isolates with an azole-resistant phenotype

Country No. azole-resistant isolates, n = 47 TR34/L98H or TR46/Y121F/T289A mechanism (no. isolates) Other mutations (no. isolates) No. isolates without Cyp51A-mutations
Austria 2 TR34/L98H (2) 0 0
Belgium 8 TR34/L98H (7) F46Y/M172G (1) 0
Denmark 6 TR34/L98H (4) 0 2
France 4 TR34/L98H (1) G54W (1) 2
Italy 5 TR34/L98H (5) 0 0
The Netherlands 7 TR34/L98H (4),
TR46/Y121F/T289A (3) 0 0
Spain 1 No isolates 0 1
Sweden 1 No isolates F46Y/M172G 0
United Kingdom
No isolates
P381R/D481E (1), L329V (1), M220K (1), L77V/L399I/D481E (1), M220I (3), M220R (1), G54R (1), G54E (1), G54W (1)
Resistant isolates, % 100 55.3 29.8 14.9

Main Article

Page created: May 15, 2015
Page updated: May 15, 2015
Page reviewed: May 15, 2015
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