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Volume 21, Number 6—June 2015
Dispatch

Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus

J.W.M. van der LindenComments to Author , M.C. Arendrup, A. Warris, K. Lagrou, H. Pelloux, P.M. Hauser, E. Chryssanthou, E. Mellado, S.E. Kidd, A.M. Tortorano, E. Dannaoui, P. Gaustad, J.W. Baddley, A. Uekötter, C. Lass-Flörl, N. Klimko, C.B. Moore, D.W. Denning, A.C. Pasqualotto, C. Kibbler, S. Arikan-Akdagli, D. Andes, J. Meletiadis, L. Naumiuk, M. Nucci, W.J.G. Melchers, and P.E. Verweij
Author affiliations: Author affiliations: Radboud University Medical Centre Nijmegen, Nijmegen, the Netherlands (J.W.M. van der Linden, W.J.G. Melchers, P.E. Verweij); Statens Serum Institute, Copenhagen, Denmark (M.C. Arendrup); University of Aberdeen, Aberdeen, UK (A. Warris); Catholic University Leuven, Leuven, Belgium (K. Lagrou); Centre Hospitalier Universitaire, Grenoble, France (H. Pelloux); Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (P.M. Hauser); Karolinska University Hospital Solna, Stockholm, Sweden (E. Chryssanthou); Instituto de Salud Carlos III, Madrid, Spain (E. Mellado); The Alfred Hospital, Melbourne, Victoria, Australia (S.E. Kidd); Università degli Studi di Milano, Milan, Italy (A.M. Tortorano); Hopital Européen G. Pompidou and Université Paris 5, Paris, France (E. Dannaoui); Oslo University Hospital and Rikshospitalet, Oslo, Norway (P. Gaustad); University of Alabama at Birmingham, Birmingham, Alabama, USA (J.W. Baddley); University of Münster, Münster, Germany (A. Uekötter); University of Innsbruck, Innsbruck, Austria (C. Lass-Flörl); North Western State Medical University, Saint Petersburg, Russia (N. Klimko); University of Manchester and Mycology Reference Centre of the University Hospital of South Manchester, Manchester, UK (C.B. Moore, D.W. Denning); Santa Casa de Misericordia de Porto Alegre and Universidade Federal de Ciencias da Saude de Porto Alegre, Porto Alegre, Brazil (A.C. Pasqualotto); Royal Free London NHS Foundation Trust and University College London, London, UK (C. Kibbler); Hacettepe University Medical School, Ankara, Turkey (S. Arikan-Akdagli); University of Wisconsin, Madison, Wisconsin, USA (D. Andes); Attikon University Hospital, Athens, Greece (J. Meletiadis); Hospital of the Medical University of Gdansk, Gdansk, Poland (L. Naumiuk); Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil (M. Nucci)

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Figure 2

Patient characteristics and underlying resistance mechanisms of patients with invasive and noninvasive Aspergillus disease. *Otomycosis, dermatomycosis, or onychomycosis; 1 patient had a resistant isolate and otomycosis (patient 9 in the online Technical Appendix Table, http://wwwnc.cdc.gov/EID/article/21/6/14-0717-Techapp1.pdf). †One patient had chronic pulmonary aspergillosis and ABPA. ‡Not classified according to European Organization for the Research and Treatment of Cancer/Mycoses Study Gro

Figure 2. Patient characteristics and underlying resistance mechanisms of patients with invasive and noninvasive Aspergillus disease. *Otomycosis, dermatomycosis, or onychomycosis; 1 patient had a resistant isolate and otomycosis (patient 9 in the online Technical Appendix Table, http://wwwnc.cdc.gov/EID/article/21/6/14-0717-Techapp1.pdf). †One patient had chronic pulmonary aspergillosis and ABPA. ‡Not classified according to European Organization for the Research and Treatment of Cancer/Mycoses Study Group criteria (5). §One patient is included with 46-bp tandem-repeat resistance mechanism. ABPA, allergic bronchopulmonary aspergillosis; CPA, chronic pulmonary aspergillosis; R, resistant; S, susceptible; –, negative; +, positive.

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References
  1. Snelders  E, van der Lee  HAL, Kuijpers  J, Rijs  AJ, Varga  J, Samson  RA, Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism. PLoS Med. 2008;5:e219. DOIPubMedGoogle Scholar
  2. van der Linden  JW, Warris  A, Verweij  PE. Aspergillus species intrinsically resistant to antifungal agents. Med Mycol. 2011;49:S82–9. DOIPubMedGoogle Scholar
  3. van der Linden  JW, Snelders  E, Kampinga  GA, Rijnders  BJ, Mattsson  E, Debets-Ossenkopp  YJ, Clinical implications of azole resistance in Aspergillus fumigatus, the Netherlands, 2007–2009. Emerg Infect Dis. 2011;17:1846–54. DOIPubMedGoogle Scholar
  4. van der Linden  JWM, Arendrup  MC, van der Lee  HAL, Melchers  WJG, Verweij  PE. Azole containing agar plates as a screening tool for azole resistance of Aspergillus fumigatus. Mycoses. 2009;52: S1–19.9.
  5. De Pauw  B, Walsh  TJ, Donnelly  JP, Stevens  DA, Edwards  JE, Calandra  T, Revised definitions of invasive fungal disease from the EORTC/MSG. Clin Infect Dis. 2008;46:1813–21. DOIPubMedGoogle Scholar
  6. Lass-Florl  C, Cuenca-Estrella  M, Denning  D, Rodriguez-Tudela  J. Antifungal susceptibility testing in Aspergillus spp. according to EUCAST methodology. Med Mycol. 2006;44:319–25. DOIGoogle Scholar
  7. van der Linden  JW, Camps  SMT, Kampinga  GA, Arends  JP, Debets-Ossenkopp  YJ, Haas  PJ, Aspergillosis due to voriconazole highly-resistant Aspergillus fumigatus and recovery of genetically related resistant isolates from domiciles. Clin Infect Dis. 2013;57:513–20. DOIPubMedGoogle Scholar

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Page updated: May 15, 2015
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