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Volume 21, Number 6—June 2015
Research

Cost-effectiveness of Chlamydia Vaccination Programs for Young Women

Kwame Owusu-EduseiComments to Author , Harrell W. Chesson, Thomas L. Gift, Robert C. Brunham, and Gail Bolan
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (K. Owusu-Edusei Jr, H.W. Chesson, T.L. Gift, G. Bolan); University of British Columbia, Vancouver, British Columbia, Canada (R.C. Brunham)

Main Article

Table 4

Summary rank regression results for select parameters used in the model to determine the health and economic outcomes of a hypothetical chlamydia vaccine

Variable/parameter* Rank coefficient† p value
Dependent variable: prevaccination prevalence in women
Proportion of women in low activity class −0.85 0.0001
Duration of infection-conferred immunity −0.77 0.0001
Per-partner probability of transmission, man to women 0.73 0.0001
Duration of asymptomatic infection in women 0.50 0.0001
Duration of asymptomatic infection in men 0.49 0.0001
Mixing parameter −0.45 0.0001
Proportion of symptomatic infections for women −0.40 0.0001
Proportion of symptomatic infections for men −0.38 0.0001
Annual screening coverage for women −0.36 0.0001
No. partners in past year, low sexual activity women 0.30 0.0001
No. partners in past year, high sexual activity women 0.30 0.012
No. partners in past year, low sexual activity men 0.27 0.013
Duration of symptomatic infection for women 0.21 0.047
Probability of postscreening treatment −0.18 0.069
Relative size of the 14-y-old population 0.12 0.091
Dependent variable: incremental cost-effectiveness ratio
Prevaccination prevalence for women −0.77 0.0001
Vaccine cost 0.71 0.0001
Duration of vaccine-conferred immunity −0.50 0.0001
Vaccine efficacy −0.45 0.0001
Probability of sequelae for women −0.32 0.0001
Discount rate 0.29 0.0001

*Only variables/parameters for which p<0.10 are shown.
†Presented in decreasing order of absolute magnitude.

Main Article

Page created: May 15, 2015
Page updated: May 15, 2015
Page reviewed: May 15, 2015
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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