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Volume 21, Number 7—July 2015

Seroprevalence for Hepatitis E and Other Viral Hepatitides among Diverse Populations, Malawi

Taha E. TahaComments to Author , Laura K. Rusie, Alain Labrique, Mulinda Nyirenda, Dean Soko, Melvin Kamanga, Johnstone Kumwenda, Homayoon Farazadegan, Kenrad Nelson, and Newton Kumwenda
Author affiliations: Johns Hopkins University, Baltimore, Maryland, USA (T.E. Taha, L.K. Rusie, A. Labrique, H. Farazadegan, K. Nelson, N. Kumwenda); Queen Elizabeth Central Hospital, Blantyre, Malawi (M. Nyirenda); Johns Hopkins Research Project, Blantyre (D. Soko, M. Kamanga); University of Malawi, Blantyre (J. Kumwenda)

Main Article

Table 1

Description of studies included in analysis of hepatitis virus seroprevalence, Malawi, 1989–2008*

Study name, period (reference) Study site/setting Study type Study population HIV status Aims of study
ICAR,1989–1994 (21,22) Queen Elizabeth Central Hospital, Blantyre/urban Observational cohort Pregnant and postpartum women +/– Assess adverse pregnancy outcomes and rates of mother-to-child transmission of HIV
SUCOMA, 1998 (23) Nchalo District, sugar estate/rural, occupational Observational survey Adult men +/– Identify epidemiologic and biologic determinants of HIV infection in an occupational male cohort
NVAZ, 2000–2004 (24) Queen Elizabeth Central Hospital, Blantyre/urban Randomized clinical trial Pregnant women + Assess efficacy of short antiretroviral post-exposure prophylaxis to prevent mother to child transmission of HIV
MWANZA, 2001 (T.E. Taha, unpub. data) Mwanza District/rural Observational survey Adult men and women +/– Assess risk factors associated with prevalent HIV infection in a rural area adjacent to the borders with Mozambique
METRO, 2003–2005 (25) Queen Elizabeth Central Hospital; health centers in Blantyre/urban Randomized clinical trial Adult women (nonpregnant) +/– Assess the efficacy of intermittent intravaginal metronidazole gel use in reducing bacterial vaginosis infection
PEPI, 2004–2008 (26) Queen Elizabeth Central Hospital; health centers in Blantyre/urban Randomized clinical trial Pregnant women + Assess efficacy of extended antiretroviral postexposure prophylaxis to prevent mother to child transmission of HIV

*ICAR, International Collaborations on AIDS Research; SUCOMA, a study of prevalence among male workers for the Sugar Company of Malawi; NVAZ, a study of efficacy of nevirapine/zidovudinel postexposure prophylaxis to prevent mother-to-child transmission of HIV; MWANZA, a study of risk factors associated with prevalent HIV infection in the rural town of Malawi; METRO, a study in which efficacy of intravaginal metronidazole gel in reducing bacterial vaginosis was assessed; PEPI, a study of antiretroviral postexposure prophylaxis to prevent mother to child transmission of HIV.

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