Volume 21, Number 8—August 2015
Synopsis
Real-Time Microbiology Laboratory Surveillance System to Detect Abnormal Events and Emerging Infections, Marseille, France
Cédric Abat, Hervé Chaudet, Philippe Colson, Jean-Marc Rolain, and Didier Raoult
Table 1
Validated alarms emitted by BALYSES and investigations from May 21, 2013 through June 4, 2014, Marseille, France*
| Pathogen | Alarm date | Abnormal event observed | Weekly mean no. samples or patients, ± 2 SDs, rounded values | Investigation | Result | Intervention |
|---|---|---|---|---|---|---|
| Klebsiella oxytoca | 2013 May 28 | Abnormal increase in no. positive samples, with 11 positive samples from 5 patients | 10 | Additional investigations did not identify any links between infected patients | False alarm | No intervention |
| Raoultella ornithinolytica | 2013 Jun 4 | Abnormal increase in no. positive samples, with 2 positive samples from 2 patients | 2 | The 2 patients were hospitalized in t same intensive care unit of same hospital | True alarm | Report sent to ARS |
| Morganella morganii | 2013 Jun 18 | Abnormal increase in no. positive samples, with 16 positive samples from 3 patients | 12 | Additional investigations did not identify any links between infected patients | False alarm | No intervention |
| Aeromonas hydrophila | 2013 Jul 7 | Abnormal increase in no. positive samples, with 1 positive sample from 1 patient | 1 | Additional investigations confirmed that patient was infected by the bacterium (leeches used to cure him were infected) | True alarm | Patient was cured with antibiotics, and report was sent to ARS |
| Enterococcus faecium | 2013 Jul 16 | Abnormal increase in no. positive samples, with 16 positive samples | 14 | Additional investigations did not identify any links between infected patients | False alarm | No intervention |
| Enterobacter aerogenes | 2013 Jul 16 | Abnormal increase in no. positive samples, with 13 positive samples | 11 | Additional investigations did not identify any links between infected patients | False alarm | No intervention |
| E. aerogenes | 2013 Jul 30 | Abnormal increase in no. positive samples, with 18 positive samples from 7 patients | 13 | Additional investigations did not identify any links between infected patients | False alarm | No intervention |
| Klebsiella oxytoca | 2013 Jul 30 | Abnormal increase in no. positive samples, with 13 positive samples from 4 patients | 10 | Additional investigations did not identify any links between infected patients | False alarm | No intervention |
| Enterobacter cloacae | 2013 Sep 3 | Abnormal increase in no. positive samples, with 31 positive samples from 15 patients | 25 | Additional investigations did not identify any links between the infected patients | False alarm | No intervention |
| Staphylococcus capitis | 2013 Oct 1 | Abnormal increase in no. patients infected, with 7 patients infected | 7 | Additional investigations did not identify any links between infected patients, and no clones were identified by MALDI-TOF spectra analysis | False alarm | No intervention |
| Staphylococcus hominis | /2013 Oct 1 | Abnormal increase in no. patients infected, with 13 patients infected | 13 | Additional investigations did not identify any links between the infected patients and no clones were identified by MALDI-TOF spectra analysis | False alarm | No intervention |
| E. cloacae | 2013 Oct 8 | Abnormal increase in no. patients infected, with 25 patients infected | 25 | True nosocomial transmission of the pathogen was identified between some infected patients | True alarm | Report sent to ARS |
| E. aerogenes | 2013 Oct 29 | Abnormal increase in no. patients infected, with 13 patients infected | 10 | True nosocomial transmission of the pathogen was identified between some infected patients | True alarm | Report sent to ARS |
| Staphylococcus gallolyticus | 2013 Nov 5 | Abnormal increase in no. patients infected, with 4 patients infected | 3 | Additional investigations did not identify any links between the infected patients and no clones were identified by MALDI-TOF spectra analysis | True alarm | No intervention |
| Gardnerella vaginalis | 2013 Dec 3 | Abnormal increase in no. patients infected, with 25 patients infected | 25 | Additional investigations did not identify any links between infected patients | True alarm | No intervention |
| Haemophilus parahaemolyticus | 2013 Dec 17 | Abnormal increase in no. patients infected, with 3 patients infected | 2 | True nosocomial transmission of the pathogen between infected patients | True alarm | Retrospective analysis of patients revealed that the bacterium was isolated from children with cystic fibrosis (whole genome sequencing of the strains is ongoing) |
| Staphylococcus saprophyticus | 2014 Jan 7 | Abnormal increase in no. patients infected, with 5 patients infected | 5 | Additional investigations did not identify any links between infected patients, and no clones were identified by MALDI-TOF spectra analysis | False alarm | No intervention |
| Escherichia coli | /2014 Jan 21 | Abnormal increase in no. patients infected, with 206 patients infected | 191 | Additional investigations did not identify any links between infected patients, and no clones were identified by MALDI-TOF spectra analysis | True alarm | No explanations were found; first results indicate that most infections come from women with community acquired urinary-tract infections |
| M. morganii | 2014 Feb 4 | Abnormal increase in no. patients infected, with 13 patients infected | 10 | Additional investigations did not identify any links between infected patients, and no clones were identified by MALDI-TOF spectra analysis | False alarm | No intervention |
| Moraxella catarrhalis | 2014 Feb 11 | Abnormal increase in no. patients infected with 3 patients infected | 2 | Additional investigations did not identify any links between infected patients, and no clones were identified by MALDI-TOF spectra analysis | False alarm | No intervention |
| Aeromonas hydrophila | 2014 Mar 11 | Abnormal increase in no. positive samples, with 1 positive sample from 1 patient | 1 | Additional investigations confirmed that patient was infected by the bacterium (leeches used to cure him were infected) | True alarm | Patient was cured with antibiotic drugs; report sent to ARS |
*BALYSES, BActerial real-time LaboratorY-based SurveillancE System; MALDI-TOF, matrix-assisted laser desorption ionization time of flight; ARS, Agence Régionale de Santé.
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