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Volume 21, Number 8—August 2015
Dispatch

Infections with Candidatus Neoehrlichia mikurensis and Cytokine Responses in 2 Persons Bitten by Ticks, Sweden

Anna Grankvist1, Lisa Labbé Sandelin1, Jennie Andersson, Linda Fryland, Peter Wilhelmsson, Per-Eric Lindgren, Pia Forsberg, and Christine WenneråsComments to Author 
Author affiliations: University of Gothenburg, Göteborg, Sweden (A. Grankvist, J. Andersson, C. Wennerås); Sahlgrenska University Hospital, Göteborg (A. Grankvist, J. Andersson, C. Wennerås); Kalmar County Hospital, Kalmar, Sweden (L.L. Sandelin); Uppsala University, Uppsala, Sweden (L.L. Sandelin); Linköping University, Linköping, Sweden (L. Fryland, P. Wilhelmsson, P.-E. Lindgren, P. Forsberg); County Hospital Ryhov, Jönköping, Sweden (P.-E. Lindgren)

Main Article

Table 2

Evolution of Candidatus Neoehrlichia mikurensis gene copy numbers and antibody levels to Borrelia burgdorferi sensu lato complex and Anaplasma phagocytophilum for patient 2, Sweden

Characteristic Days after inclusion in study
0 65 98
Clinical manifestations
 None
 Rash on left breast
 None
Candidatus N. mikurensis DNA in plasma, gene copies/mL 0 260 1300
Serum B. burgdorferi sensu lato IgM (points)* Negative (0) Negative (2) Negative (1)
B. burgdorferi sensu lato antigens
Positive reactivity
 None
 None
 None
Borderline reactivity None p39 p39
Serum B. burgdorferi sensu lato IgG (points)† Negative (0) Negative (4) Negative (4)
B. burgdorferi sensu lato antigens
Positive reactivity
 None
 VlsE
 VlsE
Borderline reactivity None None None
Serum A. phagocytophilum IgG (1:64)‡ ± + ++

*Reactivity to either outer surface protein C alone or to 2 antigens was required for a positive IgM response.
†Reactivity to >2 antigens was required for a positive IgG response.
‡Every serum sample was tested at a dilution of 1/64. ±, weakly positive; +, positive; ++, strongly positive.

Main Article

1These authors contributed equally to this article.

Page created: July 15, 2015
Page updated: July 15, 2015
Page reviewed: July 15, 2015
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