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Volume 22, Number 12—December 2016
Dispatch

Highly Pathogenic Reassortant Avian Influenza A(H5N1) Virus Clade 2.3.2.1a in Poultry, Bhutan

Atanaska Marinova-Petkova12, John Franks1, Sangay Tenzin, Narapati Dahal, Kinzang Dukpa, Jambay Dorjee, Mohammed M. Feeroz, Jerold E. Rehg, Subrata Barman, Scott Krauss, Pamela McKenzie, Richard Webby, and Robert G. WebsterComments to Author 
Author affiliations: St. Jude Children’s Research Hospital, Memphis, Tennessee, USA (A. Marinova-Petkova, J. Franks, J.E. Rehg, S. Barman, S. Krauss, P. McKenzie, R.J. Webby, R.G. Webster); National Centre for Animal Health, Ministry of Agriculture and Forests, Thimphu, Bhutan (S. Tenzin, N. Dahal, K. Dukpa, J. Dorjee); Jahangirnagar University, Dhaka, Bangladesh (M.M. Feeroz)

Main Article

Figure 2

Pathogenesis of influenza virus rH5N1 and pH5N1 2.3.2.1a genotypes in vitro and in vivo. A) Replication kinetics of rH5N1 and pH5N1 in Madin-Darby canine kidney (mammalian) cells. B) Replication kinetics of rH5N1 and pH5N1 in chicken embryonic fibroblast (avian) cells. C) Oropharyngeal shedding and transmissibility of rH5N1 and pH5N1 in a single-virus transmission model in 5-week-old White Leghorn chickens. D) Cloacal shedding and transmissibility of rH5N1 and pH5N1 in a single-virus transmissio

Figure 2. Pathogenesis of influenza virus rH5N1 and pH5N1 2.3.2.1a genotypes in vitro and in vivo. A) Replication kinetics of rH5N1 and pH5N1 in Madin-Darby canine kidney (mammalian) cells. B) Replication kinetics of rH5N1 and pH5N1 in chicken embryonic fibroblast (avian) cells. C) Oropharyngeal shedding and transmissibility of rH5N1 and pH5N1 in a single-virus transmission model in 5-week-old White Leghorn chickens. D) Cloacal shedding and transmissibility of rH5N1 and pH5N1 in a single-virus transmission model in 5-week-old White Leghorn chickens. Naive chickens were co-housed with donors infected with either Ck/22478 (pH5N1) or Ck/Bh/346 (rH5N1) (C and D). The dashed line in each panel represents the limit of virus detection. ANOVA, analysis of variance; Ck/22478, A/chicken/Bangladesh/22478; Ck/Bh/346, A/chicken/Bhutan/346/2012; Dk/BD/23126, A/duck/Bangladesh/23126; Dk/BD/19097/2013, A/duck/Bangladesh/19097; EID, egg infectious dose; dpi, days postinoculation; hpi, hours postinfection; pH5N1, pandemic H1N1; rH5N1, reassortant H5N1.

Main Article

1These authors contributed equally to this article.

2Current affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Page created: November 18, 2016
Page updated: November 18, 2016
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