Volume 22, Number 2—February 2016
Dispatch
Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus, South Korea, 2015
Table 1
Characteristics of cases and samples in a study of the microevolution of 8 isolates obtained from 4 patients during a MERS-CoV outbreak, South Korea, 2015*
Patient no., date of symptom onset | Sample type | Date of sample collection | Cycle threshold for upE/ORF1a | Transmission generation (source of transmission) |
---|---|---|---|---|
14, May 25 | Second (patient 1 to 14) | |||
Sample 1 | ETA | May 31 | 24.0/25.2 | |
Sample 2 |
Sputum |
Jun 13 |
29.0/31.5 |
|
35, May 29 | Third (patient 1 to 14 to 35) | |||
Sample 1 | Sputum | Jun 3 | 24.7/25.3 | |
Sample 2 |
Jun 18 |
27.5/28.2 |
||
168, June 17 | ETA | Fourth (patient 1 to 14 to 76 to 168) | ||
Sample 1 | Sputum | Jun 21 | 31.6/32.3 | |
Sample 2 |
Sputum |
Jun 24 |
28.9/28.3 |
|
163, June 13 | Fourth or fifth (patient 1 to ? to 52 to 119 to 163) | |||
Sample 1 | Sputum | Jun 19 | 20.2/20.9 | |
Sample 2 | Sputum | Jun 29 | 28.4/28.8 |
*ETA, endotracheal aspirate; MERS-CoV, Middle East respiratory syndrome coronavirus; ORF1a, open reading frame 1a gene; upE, upstream of E gene.
1These authors contributed equally to this article.