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Volume 22, Number 2—February 2016

Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus, South Korea, 2015

Moon-Woo Seong1, So Yeon Kim1, Victor Max Corman1, Taek Soo Kim, Sung Im Cho, Man Jin Kim, Seung Jun Lee, Jee-Soo Lee, Soo Hyun Seo, Ji Soo Ahn, Byeong Su Yu, Nare Park, Myoung-don Oh, Wan Beom Park, Ji Yeon Lee, Gayeon Kim, Joon Sung Joh, Ina Jeong, Eui Chong Kim, Christian DrostenComments to Author , and Sung Sup ParkComments to Author 
Author affiliations: Seoul National University Hospital, Seoul, South Korea (M.-W. Seong, T.S. Kim, S.I. Cho, M.J. Kim, S.J. Lee, J.-S. Lee, S.H. Seo, J.S. Ahn, B.S. Yu, N. Park, M.D. Oh, W.B. Park, E.C. Kim, S.S. Park); National Medical Center, Seoul (S.Y. Kim, J.Y. Lee, G. Kim, J.S. Joh, I. Jeong); University of Bonn Medical Centre, Bonn, Germany (V.M. Corman, C. Drosten); German Centre for Infection Research (DZIF), (V.M. Corman, C. Drosten)

Main Article

Table 1

Characteristics of cases and samples in a study of the microevolution of 8 isolates obtained from 4 patients during a MERS-CoV outbreak, South Korea, 2015*

Patient no., date of symptom onset Sample type Date of sample collection Cycle threshold for upE/ORF1a Transmission generation (source of transmission)
14, May 25 Second (patient 1 to 14)
Sample 1 ETA May 31 24.0/25.2
Sample 2
Jun 13

35, May 29 Third (patient 1 to 14 to 35)
Sample 1 Sputum Jun 3 24.7/25.3
Sample 2

Jun 18

168, June 17 ETA Fourth (patient 1 to 14 to 76 to 168)
Sample 1 Sputum Jun 21 31.6/32.3
Sample 2
Jun 24

163, June 13 Fourth or fifth (patient 1 to ? to 52 to 119 to 163)
Sample 1 Sputum Jun 19 20.2/20.9
Sample 2 Sputum Jun 29 28.4/28.8

*ETA, endotracheal aspirate; MERS-CoV, Middle East respiratory syndrome coronavirus; ORF1a, open reading frame 1a gene; upE, upstream of E gene.

Main Article

1These authors contributed equally to this article.

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