Volume 22, Number 2—February 2016
Dispatch
Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus, South Korea, 2015
Table 2
Substitution rates in strains within and between cases in a study of the microevolution of 8 isolates obtained during a MERS-CoV outbreak, South Korea, 2015*
Variable | Within cases |
Between cases |
|||||
---|---|---|---|---|---|---|---|
Days between samples | Substitutions/ observation period | Substitutions/ site/d | Days after start of transmission chain† | Substitutions/ observation period† | Substitutions/ site/d | ||
Patient no. | |||||||
14 | 13 | 1 | 2.58 × 10–6 | 30 | 3 | 3.35 × 10–6 | |
35 | 15 | 0 | 0 | 33 | 5 | 5.08 × 10–6 | |
168 | 3 | 1 | 1.12 ×10–5 | 51 | 6 | 3.94 × 10–6 | |
163 |
10 |
0 |
0 |
49 |
4 |
2.74 × 10–6 |
|
Mean (SD) | NA | NA | 3.44 × 10–6 (4.59 × 10–6) | NA | NA | 3.78 × 10–6 (8.64 × 10–7) |
*MERS-CoV, Middle East respiratory syndrome coronavirus; NA, not applicable.
†Determined on the basis of the reconstructed ancestral sequence existing on May 1, 2015.
1These authors contributed equally to this article.