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Volume 22, Number 2—February 2016

Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus, South Korea, 2015

Moon-Woo Seong1, So Yeon Kim1, Victor Max Corman1, Taek Soo Kim, Sung Im Cho, Man Jin Kim, Seung Jun Lee, Jee-Soo Lee, Soo Hyun Seo, Ji Soo Ahn, Byeong Su Yu, Nare Park, Myoung-don Oh, Wan Beom Park, Ji Yeon Lee, Gayeon Kim, Joon Sung Joh, Ina Jeong, Eui Chong Kim, Christian DrostenComments to Author , and Sung Sup ParkComments to Author 
Author affiliations: Seoul National University Hospital, Seoul, South Korea (M.-W. Seong, T.S. Kim, S.I. Cho, M.J. Kim, S.J. Lee, J.-S. Lee, S.H. Seo, J.S. Ahn, B.S. Yu, N. Park, M.D. Oh, W.B. Park, E.C. Kim, S.S. Park); National Medical Center, Seoul (S.Y. Kim, J.Y. Lee, G. Kim, J.S. Joh, I. Jeong); University of Bonn Medical Centre, Bonn, Germany (V.M. Corman, C. Drosten); German Centre for Infection Research (DZIF), (V.M. Corman, C. Drosten)

Main Article

Table 2

Substitution rates in strains within and between cases in a study of the microevolution of 8 isolates obtained during a MERS-CoV outbreak, South Korea, 2015*

Variable Within cases
Between cases
Days between samples Substitutions/ observation period Substitutions/ site/d Days after start of transmission chain† Substitutions/ observation period† Substitutions/ site/d
Patient no.
14 13 1 2.58 × 10–6 30 3 3.35 × 10–6
35 15 0 0 33 5 5.08 × 10–6
168 3 1 1.12 ×10–5 51 6 3.94 × 10–6

2.74 × 10–6
Mean (SD) NA NA 3.44 × 10–6 (4.59 × 10–6) NA NA 3.78 × 10–6 (8.64 × 10–7)

*MERS-CoV, Middle East respiratory syndrome coronavirus; NA, not applicable.
†Determined on the basis of the reconstructed ancestral sequence existing on May 1, 2015.

Main Article

1These authors contributed equally to this article.

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