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Volume 22, Number 4—April 2016
Dispatch

Adenovirus Type 7 Pneumonia in Children Who Died from Measles-Associated Pneumonia, Hanoi, Vietnam, 2014

Le Thanh Hai, Hoang Ngoc Thach, Ta Anh Tuan, Dao Huu Nam, Tran Minh Dien, Yuko Sato, Toshio Kumasaka, Tadaki Suzuki, Nozomu Hanaoka, Tsuguto Fujimoto, Harutaka Katano, Hideki Hasegawa, Shoji Kawachi, and Noriko NakajimaComments to Author 
Author affiliations: The National Hospital of Pediatrics, Hanoi, Vietnam (L.T. Hai, H.N. Thach, T.A. Tuan, D.H. Nam, T.M. Dien); National Institute of Infectious Diseases, Tokyo, Japan (Y. Sato, T. Suzuki, N. Hanaoka, T. Fujimoto, H. Katano, H. Hasegawa, N. Nakajima); Japanese Red Cross Medical Center, Tokyo (T. Kumasaka); Tomakomai City Hospital, Tomakomai, Japan (S. Kawachi)

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Table 2

Histologic findings and detection of virus genomes and antigens in postmortem lung tissues of 16 children who died from measles-associated pneumonia in a pediatric intensive care unit, National Hospital of Pediatrics, Hanoi, Vietnam, February–June 2014*

Analysis
 Patient no.
1
 2
 3
 4
 5
 6
 7
 8
 9
 10
 11
 12
 13
 14
 15
 16
Histology
Diffuse alveolar damage No Yes Yes Yes No Yes Yes Yes No Yes Yes Yes Yes Yes Yes No
Necrotizing pneumonia No No Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes No No No Yes
Interstitial pneumonia Yes No No No No No No No No No No No No No No No
Organizing pneumonia No No No No No No No No No No No No Yes Yes Yes No
Bacterial pneumonia No No No No No No No No No No No No No No No Yes
Viral Inclusion body
 Yes
 Yes
 Yes
 Yes
 Yes
 Yes
 Yes
 Yes
 Yes
 Yes
 Yes
 Yes
 No
 No
 No
 No
Virus genome in FFPE lung†
Measles virus RNA 3+ NA UD UD UD UD UD UD NA NA NA NA UD UD NA UD
AdV7 DNA UD NA 5+ 7+ 6+ 3+ 5+ 7+ NA NA NA NA UD UD NA UD
Cytomegalovirus DNA
 UD
 NA
 UD
 UD
 UD
 UD
 2+
 UD
 NA
 NA
 NA
 NA
 3+
 4+
 NA
 UD
Immunohistochemistry
Measles virus + + – – – – – – – – – – – – – –
AdV – – + + + + + + + + + + – – – –
Cytomegalovirus – – – – – – – – – – – – + – – –

*+, positive; –, negative; AdV; adenovirus; AdV7, adenovirus type 7; FFPE, formalin-fixed and paraffin-embedded; NA, not available because the specimen sizes were too small for analysis; RT-PCR, reverse transcription PCR; UD, under detection limit.
†Virus genome copy numbers were quantified by using real-time RT-PCR or real-time PCR: 2+, 102–103 copies/μL; 3+, 103–104 copies/μL; 4+, 104–105 copies/μL; 5+, 105–106 copies/μL; 6+, 106–107 copies/μL; 7+, 107–108 copies/μL.

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Page created: March 16, 2016
Page updated: March 16, 2016
Page reviewed: March 16, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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