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Volume 22, Number 4—April 2016

Research

Evaluation of Viremia Frequencies of a Novel Human Pegivirus by Using Bioinformatic Screening and PCR

David Bonsall, William F. Gregory, Camilla L.C. Ip, Sharyne Donfield, James Iles, M. Azim Ansari, Paolo Piazza, Amy Trebes, Anthony Brown, John Frater, Oliver G. Pybus, Phillip Goulder, Paul Klenerman, Rory Bowden, Edward D. Gomperts, Eleanor Barnes, Amit Kapoor, Colin P. Sharp, and Peter SimmondsComments to Author 
Author affiliations: University of Oxford, Oxford, UK (D. Bonsall, C.L.C. Ip, J. Iles, M.A. Ansari, P. Piazza, A. Trebes, A. Brown, J. Frater, O.G. Pybus, P. Goulder, P. Klenerman, R. Bowden, E. Barnes, P. Simmonds); University of Edinburgh Easter Bush, Edinburgh, Scotland, UK (W.F. Gregory, C.P. Sharp); Rho, Inc., Chapel Hill, North Carolina, USA (S. Donfield); The Childrens' Hospital, Los Angeles, California, USA (E.D. Gomperts); The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA (A. Kapoor)

Main Article

Table 2

Detection frequencies of HPgV by sequence library screening and PCR*

Diagnostic method Diagnoses and characteristics No. tested No. (%) HHpgV-1+ No. (%) HPgV+
Bioinformatics
HIV+ 36 0 3 (8.3)
HIV+/HCV+/PWID 30 0 3 (10.0)
HCV+/PWID
 120
 2 (1.7)
 14 (11.6)
PCR
Hemophilia† 195 1 (0.5) 18 (9.2)
Control group‡ 50 0 1 (2.0)

*HPgV, human pegivirus; HHpgV, human hepegivirus; +, positive;HCV, hepatitis C virus; PWID, persons who inject drugs.
†Previously exposed to virally inactivated factor VIII/IX; all seropositive for HCV.
‡No history of parenteral exposure; HIV-1 and HCV negative.

Main Article

Page created: March 15, 2016
Page updated: March 15, 2016
Page reviewed: March 15, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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