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Volume 22, Number 8—August 2016
Research

Phylogeographic Evidence for 2 Genetically Distinct Zoonotic Plasmodium knowlesi Parasites, Malaysia

Ruhani Yusof1, Md Atique Ahmed1, Jenarun Jelip, Hie Ung Ngian, Sahlawati Mustakim, Hani Mat Hussin, Mun Yik Fong, Rohela Mahmud, Frankie Anak Thomas Sitam, J. Rovie-Ryan Japning, Georges Snounou, Ananias A. Escalante, and Yee Ling LauComments to Author 
Author affiliations: University of Malaya Faculty of Medicine, Kuala Lumpur, Malaysia (R. Yusof, M.A. Ahmed, M.Y. Fong, R. Mahmud, Y.L. Lau); Sabah State Health Department, Sabah, Malaysia (J. Jelip); Hospital Kapit, Sarawak, Malaysia (H.U. Ngian); Hospital Tengku Microbiology Laboratory, Ampuan Rahimah, Selangor, Malaysia (S. Mustakim); Kelantan State Health Department, Kelantan, Malaysia (H.M. Hussin); Department of Wildlife and National Parks Peninsular Malaysia, Kuala Lumpur, Malaysia (F.A.T. Sitam, J. Rovie-Ryan); Sorbonne Universités, INSERM, Paris, France (G. Snounou); Temple University, Philadelphia, PA, USA (G. Snounou, A.A. Escalante)

Main Article

Table 5

FST results for pairwise population comparisons of 2 genetically distinct zoonotic Plasmodium knowlesi parasite populations and associated significance, Malaysia*†

Gene and location Haplotype FST values
HuPen MaPen HuBor MaBor
PkA-type 18S rRNA
Peninsular Malaysia HuPen NA ‡ ‡ ‡
MaPen 0.0483 NA ‡ ‡
Malaysian Borneo HuBor 0.2710 0.2167 NA NS
MaBor
 0.3134
 0.3090
 0.0008
 NA
PkCOX1
Peninsular Malaysia HuPen NA § ‡ ‡
MaPen 0.0461 NA ‡ ‡
Malaysian Borneo HuBor 0.6008 0.6303 NA NS
MaBor 0.6219 0.6925 0.0007 NA

*HuBor, human haplotypes from Malaysian Borneo; HuPen, human haplotypes from Peninsular Malaysia; MaBor, Macaque haplotypes from Malaysian Borneo; MaPen, macaque haplotype from Peninsular Malaysia; NA, not applicable; NS, not significant; PkA-type 18S rRNA, P. knowlesi type A small subunit ribosomal 18S RNA; PkCOX1 P. knowlesi cytochrome oxidase subunit I.
†ARLEQUIN (University of Berne, Berne, Switzerland) software package version 3.5.1.3 was used to compute pairwise differences between populations (i.e., humans and macaques from Peninsular Malaysia and Malaysian Borneo).
‡p<0.001; p values computed with 10,100 permutations.
§p<0.05.

Main Article

1These authors contributed equally to this article.

Page created: July 15, 2016
Page updated: July 15, 2016
Page reviewed: July 15, 2016
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