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Volume 23, Number 10—October 2017

Research

Poliovirus Excretion in Children with Primary Immunodeficiency Disorders, India

Madhu Chhanda MohantyComments to Author , Manisha Rajan Madkaikar, Mukesh Desai, Prasad Taur, Uma Prajwal Nalavade, Deepa Kailash Sharma, Maya Gupta, Aparna Dalvi, Snehal Shabrish, Manasi Kulkarni, Jahnavi Aluri, and Jagadish Mohanrao Deshpande
Author affiliations: Enterovirus Research Centre, Mumbai, Maharashtra, India (M.C. Mohanty, U.P. Nalavade, D.K. Sharma, J.M. Deshpande); National Institute of Immunohaematology, Mumbai (M.R. Madkaikar, M. Gupta, A. Dalvi, S. Shabrish, M. Kulkarni, J. Aluri); Bai Jerbai Wadia Children’s Hospital, Mumbai (M. Desai, P. Taur)

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Table 2

Demographic and clinical data for patients with PID whose fecal samples tested positive for polioviruses, Wadia Children’s Hospital, Mumbai, India, September 2014–April 2017*

Serial no. Age, mo/ sex PID type Months last OPV† IVIG
therapy BMT Results by collection day
1 48/M SCID 37 Yes ND D1, VDPV3; D91, VDPV3; D175, VDPV3; D207, VDPV3; D263, VDPV3; D334, VDPV3; D369, VDPV3; D454, VDPV3; D488, VDPV3; D524, VDPV3; D550, VDPV3; D634, VDPV3; D700, VDPV3; D774, neg; D799, Neg; D840, neg; D930, neg
2 48/M FLH NA No ND D1, neg; D49, P1SL; D128, neg; D241, neg
3 4/M SCID 4 Yes ND D1, P1SL; D29, P1SL

*BMT, bone marrow transplant; D, day of collection following first collection; FLH, familial lymphohistiocytosis; IVIG, intravenous immunoglobulin; NA, not available; ND, not done; neg, negative; OPV, oral polio vaccine; P1SL, polio1 Sabin-like; P3SL, polio 3 Sabin-like; PID, primary immunodeficiency disease; SCID, severe combined immunodeficiency; VDPV3, type 3 vaccine-derived poliovirus.
†Time from last OPV to first fecal sample collection.

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