Volume 23, Number 11—November 2017
Research
Drug-Resistant Tuberculosis among Children, China, 2006–2015
Ning-ning Tao, Xiao-chun He, Xian-xin Zhang, Yao Liu, Chun-bao Yu, and Huai-chen Li
Table 2
First-line drug resistance found for 14,233 new cases of TB, Shandong Province, China, 2006–2015*
| Drug resistance | <18 y, no. (%), n = 784 | >18 y, no. (%), n = 13,439 | p value |
|---|---|---|---|
| Any resistance to first-line drug | 148 (18.88) | 2,853 (21.23) | 0.12 |
| INH | 95 (12.12) | 1,884 (14.02) | 0.14 |
| RIF | 65 (8.29) | 1,112 (8.27) | 0.99 |
| EMB | 43 (5.48) | 449 (3.34) | 0.001 |
| SM |
112 (14.29) |
2,084 (15.51) |
0.36 |
| Resistance to 1 drug | 67 (8.55) | 1,323 (9.84) | 0.23 |
| INH | 20 (2.55) | 445 (3.31) | 0.25 |
| RIF | 5 (0.64) | 129 (0.96) | 0.36 |
| EMB | 3 (0.38) | 33 (0.25) | 0.45 |
| SM |
39 (4.97) |
716 (5.33) |
0.67 |
| Resistance to 2 drugs | 27 (3.44) | 683 (5.08) | 0.04 |
| INH + RIF | 3 (0.38) | 113 (0.84) | 0.22 |
| INH + EMB | 2 (0.26) | 30 (0.22) | 0.70 |
| INH + SM | 17 (2.17) | 459 (3.42) | 0.06 |
| RIF + EMB | 1 (0.13) | 4 (0.03) | 0.25 |
| RIF + SM | 4 (0.51) | 74 (0.55) | 1.00 |
| SM + EMB |
0 |
3 (0.02) |
NA |
| Resistance to 3 drugs | 22 (2.81) | 548 (4.08) | 0.08 |
| INH + RIF + EMB | 2 (0.26) | 15 (0.11) | 0.24 |
| INH + RIF + SM | 17 (2.17) | 468 (3.48) | 0.05 |
| INH + EMB + SM | 2 (0.26) | 55 (0.41) | 0.77 |
| RIF + EMB + SM |
1 (0.13) |
10 (0.07) |
0.46 |
| Resistance to at least INH/RIF | 52 (6.63) | 1,206 (8.97) | 0.03 |
| Multidrug resistant, overall | 54 (6.88) | 895 (6.66) | 0.80 |
| Resistance to 4 drugs | 32 (4.08) | 299 (2.22) | 0.001 |
*EMB, ethambutol; INH, isoniazid; NA, not applicable; RIF, rifampin; SM, streptomycin; TB, tuberculosis.
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