Outbreak of Yellow Fever among Nonhuman Primates, Espirito Santo, Brazil, 2017
Natália Coelho Couto de Azevedo Fernandes
, Mariana Sequetin Cunha, Juliana Mariotti Guerra, Rodrigo Albergaria Réssio, Cinthya dos Santos Cirqueira, Silvia D’Andretta Iglezias, Júlia de Carvalho, Emerson L.L. Araujo, José Luiz Catão-Dias, and Josué Díaz-Delgado
Author affiliations: Instituto Adolfo Lutz, São Paulo, Brazil (N.C.C.A. Fernandes, M.S. Cunha, J.M. Guerra, R.A. Réssio, C.S. Cirqueira, S. D’Andretta Iglezias, J. de Carvalho, J. Díaz-Delgado); Ministério da Saúde, Brasília, Brazil (E.L.L. Araujo); Universidade de São Paulo, São Paulo (J.L. Catão-Dias, J. Díaz-Delgado)
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Figure 2
Figure 2. Histopathologic and immunohistochemical findings in the livers of neotropical nonhuman primates that died of yellow fever, Espirito Santo, Brazil, January 2017. Asterisks (*) indicate centrilobular veins. A) Midzonal and centrilobular bridging hepatocellular lytic necrosis. Original magnification ×40; hematoxylin and eosin (H&E) staining. Inset shows lytic hepatocellular necrosis with multiple Councilman-Rocha Lima (apoptotic) bodies (arrows). Original magnification ×400; H&E staining. B) Massive (diffuse) hepatocellular lytic necrosis with severe centrilobular and midzonal hemorrhage. Original magnification ×40; H&E staining. Inset shows prominent hepatocellular necrosis and dropout, and erythrocytes replace the hepatic cords (there is some artifactual formalin pigment [acid hematin] in necrotic hepatocytes). Original magnification ×400; H&E staining. C) Massive macrovacuolar steatosis. Inset shows massive macrovacuolar steatosis mingled with single-cell hepatocellular necrosis (arrow). Original magnification ×400; H&E staining. D) Positive immunolabeling confined to remaining periportal hepatocytes and terminal plate. Original magnification ×40; immunohistochemical staining for yellow fever virus. Inset shows positive granular, cytoplasmic immunolabeling for yellow fever virus antigen in periportal hepatocytes and terminal plate. Original magnification ×400; immunohistochemical staining for yellow fever virus.
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Page updated: November 16, 2017
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