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Volume 23, Number 2—February 2017

Dispatch

mcr-1−Harboring Salmonella enterica Serovar Typhimurium Sequence Type 34 in Pigs, China

Linxian Yi1, Jing Wang1, Yanling Gao, Yiyun Liu, Yohei Doi, Renjie Wu, Zhenling Zeng, Zisen Liang, and Jian-Hua LiuComments to Author 
Author affiliations: South China Agricultural University, Guangzhou, China (L. Yi, J. Wang, Y. Liu, R. Wu, Z. Zeng, Z. Liang, J.-H. Liu); Henan General Institute of Animal Drugs and Feedstuff, Zhengzhou, China (Y. Gao); University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA (Y. Doi)

Main Article

Table

Characteristics of mcr-1–positive Salmonella isolates from pigs at slaughter, China, 2013–2014*

Strain Serovar PFGE type Sequence type S1-PFGE, plasmid, kb Colistin MIC, mg/L Polymyxin B MIC, mg/L Other antimicrobial drug resistance† Resistance gene‡
SH149 Typhimurium A5 34 ≈180 2 4 AMP, STR, GEN, FFC, SXT, TET floR, oqxAB
SH143 Typhimurium A1 34 ≈180 2 4 AMP, STR, GEN, FFC, SXT, TET floR, oqxAB
SH138 Typhimurium A1 34 ≈180 2 4 AMP, STR, GEN, FFC, SXT, TET floR, oqxAB
SH93 Typhimurium A1 34 ≈180 2 8 FFC, SXT, TET floR, oqxAB
SH33 Typhimurium A1 34 ≈110 2 4 AMP, STR, SXT, TET oqxAB
SH137 Typhimurium A1 34 ≈180 2 8 AMP, STR, GEN, FFC, SXT, TET floR, oqxAB
SA316 Typhimurium A1 34 ≈180 2 8 AMP, STR, GEN, FFC, SXT, TET floR
SH127 Typhimurium A1 34 ≈180 2 4 AMP, STR, GEN, FFC, SXT, TET floR, oqxAB
SH128 Typhimurium A1 34 ≈180 2 4 AMP, STR, GEN, FFC, SXT, TET floR, oqxAB
SH133 Typhimurium A1 34 ≈180 2 4 AMP, STR, GEN, FFC, SXT, TET floR, oqxAB
SH134 Typhimurium A1 34 ≈180 2 4 AMP, STR, GEN, FFC, SXT, TET floR, oqxAB
SH17 Typhimurium A1 34 ≈180 2 4 AMP, STR, GEN, FFC, SXT, TET floR, oqxAB
SH239 Typhimurium A1 34 ≈180, ≈138 2 8 AMP, STR, GEN, FFC, SXT, TET floR
SH271 Typhimurium A1 34 ≈180 2 8 AMP, STR, GEN, FFC, SXT, TET floR, oqxAB
SH83 Typhimurium A1 34 ≈180 2 4 AMP, STR, GEN, FFC, SXT, TET floR, oqxAB
SH205 Typhimurium A1 34 ≈180 2 8 AMP, STR, GEN, FFC, SXT, TET floR, oqxAB
SH39 Typhimurium A2 34 ≈180 2 4 AMP, STR, GEN, FFC, SXT, TET floR, oqxAB
SH178 Typhimurium A1 34 ≈180 2 4 AMP, STR, GEN, FFC, SXT, TET floR, oqxAB
SH175§ Typhimurium A4 34 ≈180 2 8 AMP, STR, GEN, FFC, SXT, TET floR, oqxAB
SH36§ Heidelberg B ND ≈180 2 8 STR, FFC, SXT floR, oqxAB
Z4P319S§ London C ND ≈180 1 2 AMP, STR, GEN, FFC,CIP, SXT, TET floR, oqxAB

*According to recommendations of the joint Clinical and Laboratory Standards Institute (CLSI)–European Committee on Antimicrobial Susceptibility Testing (EUCAST) and the Polymyxin Breakpoints Working Group (http://www.eucast.org/), the International Organization for Standardization standard broth microdilution method (20776–1) was used to determine colistin MICs for these strains. Antimicrobial susceptibility was determined and evaluated according to CLSI document no. M100-S25 (http://shop.clsi.org/site/Sample_pdf/M100S25_sample.pdf). Resistance to florfenicol was interpreted according to EUCAST clinical breakpoints and epidemiological cutoff values (>16 mg/L) (http://mic.eucast.org/Eucast2/). MICs of olaquindox for all isolates, except SH36, were >64 mg/L. AMP, ampicillin; CIP, ciprofloxacin; FFC, florfenicol; GEN, gentamicin; ND, not determined; STR, streptomycin; SXT, sulfamethoxazole/trimethoprim; TET, tetracycline.
†Boldface indicates resistance phenotypes transferred to a recipient by transformation.
‡Boldface indicates resistance genes transferred to a recipient by transformation.
§Original strains of transformants.

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1These authors contributed equally to this article.

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