Volume 23, Number 3—March 2017
Research
Pulmonary Nontuberculous Mycobacteria–Associated Deaths, Ontario, Canada, 2001–2013
Table 3
Survival estimates for patients with pulmonary NTM and for matched controls, Ontario, Canada, 2001–2013*
Group |
Any NTM (isolation or disease) |
NTM isolation only |
NTM disease |
||||||||
Total |
5-y survival, % |
HR (95% CI) |
Total |
5-y survival, % |
HR (95% CI) |
Total |
5-y survival, % |
HR (95% CI) |
|||
NTM | 18,436 | 71.3 | 1.47 (1.42–1.51) | 9,967 | 76.1 | 1.33 (1.27–1.39) | 8,469 | 65.6 | 1.63 (1.56–1.70) | ||
Control |
18,436 |
80.8 |
1.00 (ref) |
9,967 |
82.6 |
1.00 (ref) |
8,469 |
78.7 |
1.00 (ref) |
||
MAC | 10,785 | 71.2 | 1.45 (1.39–1.51) | 5,242 | 75.9 | 1.33 (1.25–1.41) | 5,543 | 66.7 | 1.57 (1.48–1.66) | ||
Control |
10,785 |
80.4 |
1.00 (ref) |
5,242 |
82.3 |
1.00 (ref) |
5,543 |
78.5 |
1.00 (ref) |
||
M. xenopi | 4,668 | 68.3 | 1.54 (1.45–1.64) | 2,693 | 74.5 | 1.32 (1.22–1.44) | 1,975 | 59.9% | 1.84 (1.69–2.01) | ||
Control |
4,668 |
79.9 |
1.00 (ref) |
2,693 |
81.5 |
1.00 (ref) |
1,975 |
77.7% |
1.00 (ref) |
||
M. fortuitum | 890 | 76.4% | 1.39 (1.21–1.60) | 654 | 78.8 | 1.47 (1.24–1.73) | 236 | 69.7 | 1.25 (0.96–1.63) | ||
Control |
890 |
84.9% |
1.00 (ref) |
654 |
86.4 |
1.00 (ref) |
236 |
80.7 |
1.00 (ref) |
||
M. abscessus | 363 | 80.5 | 1.45 (1.09–1.92) | 162 | 82.2 | 1.39 (0.94–2.07) | 201 | 79.2 | 1.49 (1.00–2.21) | ||
Control |
363 |
86.6 |
1.00 (ref) |
162 |
85.7 |
1.00 (ref) |
201 |
87.3 |
1.00 (ref) |
||
M. kansasii | 236 | 60.2 | 2.29 (1.76–2.97) | 92 | 55.3% | 2.02 (1.37–3.00) | 144 | 63.5 | 2.53 (1.78–3.58) | ||
Control |
236 |
84.0 |
1.00 (ref) |
92 |
85.3% |
1.00 (ref) |
144 |
83.0 |
1.00 (ref) |
||
Other species | 1,494 | 77.7 | 1.28 (1.13–1.43) | 1124 | 80.0% | 1.20 (1.04–1.38) | 370 | 70.7 | 1.51 (1.22–1.88) | ||
Control | 1,494 | 82.4 | 1.00 (ref) | 1124 | 83.2% | 1.00 (ref) | 370 | 79.8 | 1.00 (ref) |
*Matched by age (years), sex, index date (± 90 d), and propensity score (estimating the patient-level likelihood of species–condition combinations) value within 0.2 × SD of the exposed patient. NTM isolation was defined as 1 positive sputum specimen for NTM. NTM disease was defined as >1 positive sputum for the same species or 1 positive bronchoscopic or biopsy specimen. Controls were persons without NTM matched by age, sex, index date, and propensity score. HR, hazard ratio; MAC, Mycobacterium avium complex; NTM, nontuberculous mycobacterium; ref, referent.
1These authors contributed equally to this article.