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Volume 23, Number 4—April 2017

Dispatch

Assessing Sensitivity and Specificity of Surveillance Case Definitions for Zika Virus Disease

Angela ChowComments to Author , Hanley Ho, Mar-Kyaw Win, and Yee-Sin Leo
Author affiliations: Tan Tock Seng Hospital, Singapore

Main Article

Table 2

Performance of case definitions for diagnosing Zika virus infection in a human cohort during an outbreak, Singapore, August 26–September 5, 2016*

Case definition Sensitivity, % Specificity, % PPV, % NPV, % LR+ (95% CI) LR– (95% CI)
United States 100 2 42 100 1.02 (1.00–1.04) 0
WHO 38 70 47 61 1.3 (0.9–1.7) 0.9 (0.8–1.0)
PAHO 49 76 59 68 2.1 (1.5–2.8) 0.7 (0.6–0.8)
ECDC 56 74 60 70 2.1 (1.6–2.8) 0.6 (0.5–0.7)
Singapore MOH 54 76 61 70 2.2 (1.7–3.0) 0.6 (0.5–0.7)

*ECDC, European Centre for Disease Prevention and Control; LR, likelihood ratio; MOH, Ministry of Health; NPV, negative predictive value; PAHO, Pan American Health Organization; PPV, positive predictive value; WHO, World Health Organization; +, positive; –, negative.

Main Article

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