Volume 23, Number 4—April 2017
Dispatch
Assessing Sensitivity and Specificity of Surveillance Case Definitions for Zika Virus Disease
Angela Chow
, Hanley J. Ho, Mar-Kyaw Win, and Yee-Sin Leo
, Hanley J. Ho, Mar-Kyaw Win, and Yee-Sin Leo
Table 2
Performance of case definitions for diagnosing Zika virus infection in a human cohort during an outbreak, Singapore, August 26–September 5, 2016*
| Case definition | Sensitivity, % | Specificity, % | PPV, % | NPV, % | LR+ (95% CI) | LR– (95% CI) |
|---|---|---|---|---|---|---|
| United States | 100 | 2 | 42 | 100 | 1.02 (1.00–1.04) | 0 |
| WHO | 38 | 70 | 47 | 61 | 1.3 (0.9–1.7) | 0.9 (0.8–1.0) |
| PAHO | 49 | 76 | 59 | 68 | 2.1 (1.5–2.8) | 0.7 (0.6–0.8) |
| ECDC | 56 | 74 | 60 | 70 | 2.1 (1.6–2.8) | 0.6 (0.5–0.7) |
| Singapore MOH | 54 | 76 | 61 | 70 | 2.2 (1.7–3.0) | 0.6 (0.5–0.7) |
*ECDC, European Centre for Disease Prevention and Control; LR, likelihood ratio; MOH, Ministry of Health; NPV, negative predictive value; PAHO, Pan American Health Organization; PPV, positive predictive value; WHO, World Health Organization; +, positive; –, negative.
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Page updated: March 17, 2017
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