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Volume 23, Number 4—April 2017

Dispatch

Severe Thrombocytopenia after Zika Virus Infection, Guadeloupe, 2016

Timothée Boyer Chammard, Kinda Schepers, Sébastien Breurec, Thierry Messiaen, Anne-Laure Destrem, Matthieu Mahevas, Adrien Soulillou, Ludovic Janaud, Elodie Curlier, Cécile Herrmann-Storck, and Bruno HoenComments to Author 
Author affiliations: Centre Hospitalier Universitaire, Pointe-à-Pitre, France (T. Boyer Chammard, K. Schepers, S. Breurec, T. Messiaen, A.-L. Destrem, A. Soulillou, L. Janaud, E. Curlier, C. Herrmann-Storck, B. Hoen); Institut National de la Santé et de la Recherche Médicale, Pointe-à-Pitre (K. Schepers, B. Hoen); Institut Pasteur de Guadeloupe, Pointe-à-Pitre (S. Breurec); Université des Antilles, Pointe-à-Pitre (S. Breurec, B. Hoen); Centre Hospitalier Universitaire Henri Mondor, Créteil, France (M. Mahevas)

Main Article

Table

Characteristics of 16 patients with severe thrombocytopenia associated with Zika virus infection*

Pt no./ age, y/sex Country Hemorrhagic signs and symptoms Min platelet count, × 109/L Days to min platelet count† Steroid therapy IVIG Outcome Reference
RT-PCR result
Zika virus
 DENV
Urine Plas Urine Plas
1/38/F Guadeloupe Yes 17 3 + – – – Yes No Recovered This study
2/58/F Guadeloupe Yes 3 6 + + – – Yes Yes Recovered This study
3/15/F Guadeloupe Yes 2 19 + + – – Yes No Recovered This study
4/36/M Guadeloupe Yes 5 8 + – – – Yes No Recovered This study
5/74/F Guadeloupe Yes 1 5 + – – – Yes No Recovered This study
6/46/F Guadeloupe Yes 1 12 + Unk – Unk Yes Yes Recovered This study
7/35/M Guadeloupe Yes 1 4 + – – – Yes Yes Recovered This study
8/54/F Suriname Yes 10 29 + – – Unk No Yes Recovered (10)
9/2/F Colombia Yes <14 Unk Unk + Unk – Unk Unk Died (11)
10/30/F Colombia Yes <14 Unk Unk + Unk – Unk Unk Died (11)
11/72/F Colombia Yes <14 Unk Unk + Unk – Unk Unk Died (11)
12/72/M Puerto Rico Yes 1 5 Unk + Unk – No No Died (13)
13/38/M Puerto Rico Yes 2 7 – – Unk – Yes Yes Recovered (13)
14/26/F Martinique Yes 2 8 + – Unk – Yes No Recovered (14)
15/21/M Martinique Yes 3 7 + – Unk – Yes No Recovered (14)
16/30/F Colombia No 9 4 + – Unk Unk No No Recovered (12)

*DENV, dengue virus; IVIG, intravenous immune globulins; min, minimum; plas, plasma; pt, patient; unk, unknown.
†From Zika onset.

Main Article

Page created: March 17, 2017
Page updated: March 17, 2017
Page reviewed: March 17, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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