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Volume 23, Number 4—April 2017

Dispatch

Severe Thrombocytopenia after Zika Virus Infection, Guadeloupe, 2016

Timothée Boyer Chammard, Kinda Schepers, Sébastien Breurec, Thierry Messiaen, Anne-Laure Destrem, Matthieu Mahevas, Adrien Soulillou, Ludovic Janaud, Elodie Curlier, Cécile Herrmann-Storck, and Bruno HoenComments to Author 
Author affiliations: Centre Hospitalier Universitaire, Pointe-à-Pitre, France (T. Boyer Chammard, K. Schepers, S. Breurec, T. Messiaen, A.-L. Destrem, A. Soulillou, L. Janaud, E. Curlier, C. Herrmann-Storck, B. Hoen); Institut National de la Santé et de la Recherche Médicale, Pointe-à-Pitre (K. Schepers, B. Hoen); Institut Pasteur de Guadeloupe, Pointe-à-Pitre (S. Breurec); Université des Antilles, Pointe-à-Pitre (S. Breurec, B. Hoen); Centre Hospitalier Universitaire Henri Mondor, Créteil, France (M. Mahevas)

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Table

Characteristics of 16 patients with severe thrombocytopenia associated with Zika virus infection*

Pt no./ age, y/sex Country Hemorrhagic signs and symptoms Min platelet count, × 109/L Days to min platelet count† Steroid therapy IVIG Outcome Reference
RT-PCR result
Zika virus
DENV
Urine Plas Urine Plas
1/38/F Guadeloupe Yes 17 3 + Yes No Recovered This study
2/58/F Guadeloupe Yes 3 6 + + Yes Yes Recovered This study
3/15/F Guadeloupe Yes 2 19 + + Yes No Recovered This study
4/36/M Guadeloupe Yes 5 8 + Yes No Recovered This study
5/74/F Guadeloupe Yes 1 5 + Yes No Recovered This study
6/46/F Guadeloupe Yes 1 12 + Unk Unk Yes Yes Recovered This study
7/35/M Guadeloupe Yes 1 4 + Yes Yes Recovered This study
8/54/F Suriname Yes 10 29 + Unk No Yes Recovered (10)
9/2/F Colombia Yes <14 Unk Unk + Unk Unk Unk Died (11)
10/30/F Colombia Yes <14 Unk Unk + Unk Unk Unk Died (11)
11/72/F Colombia Yes <14 Unk Unk + Unk Unk Unk Died (11)
12/72/M Puerto Rico Yes 1 5 Unk + Unk No No Died (13)
13/38/M Puerto Rico Yes 2 7 Unk Yes Yes Recovered (13)
14/26/F Martinique Yes 2 8 + Unk Yes No Recovered (14)
15/21/M Martinique Yes 3 7 + Unk Yes No Recovered (14)
16/30/F Colombia No 9 4 + Unk Unk No No Recovered (12)

*DENV, dengue virus; IVIG, intravenous immune globulins; min, minimum; plas, plasma; pt, patient; unk, unknown.
†From Zika onset.

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