Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 23, Number 5—May 2017
Dispatch

Survey of Treponemal Infections in Free-Ranging and Captive Macaques, 1999–2012

Amy R. Klegarth, Chigozie A. Ezeonwu, Aida Rompis, Benjamin P.Y.-H. Lee, Nantiya Aggimarangsee, Mukesh Chalise, John Cortes, M. Feeroz, Barbara J. Molini, Bess C. Godornes, Michael Marks, Michael Schillaci, Gregory Engel, Sascha Knauf, Sheila A. Lukehart, and Lisa Jones-EngelComments to Author 
Author affiliations: University of Washington, Seattle, Washington, USA (A.R. Klegarth, C.A. Ezeonwu, B.J. Molini, B.C. Godornes, S.A. Lukehart, L. Jones-Engel); Udayana University, Denpasar, Bali, Indonesia (A. Rompis); University of Kent, Canterbury, UK (B.P.Y-H. Lee); Chiang Mai University, Chiang Mai, Thailand (N. Aggimarangsee); Tribhuvan University, Kirtipu, Nepal (M. Chalise); HM Government of Gibraltar, Gibraltar, Gibraltar (J. Cortes); Jahangirnagar University, Dhaka, Bangladesh (M. Feeroz); London School of Hygiene and Tropical Medicine, London, UK (M. Marks); University of Toronto Scarborough, Toronto, Ontario, Canada (M. Schillaci); Samuel Simmonds Memorial Hospital, Barrow, Alaska, USA (G. Engel); German Primate Center, Gottingen, Germany (S. Knauf)

Main Article

Figure

Individual sampling sites where macaques were tested for infection with Treponema spp. during 1999–2012 and the number of human yaws cases during 2001–2011, Sulawesi, Indonesia. Numbers in parentheses indicate number nonhuman primates sampled in each of the 6 provinces. ESPLINE TP (Fujirebio Inc., Tokyo, Japan) reagent for the detection of T. pallidum antibodies was used to determine whether macaque samples were positive for treponemal infection. The number of human yaws cases was determined by

Figure. Individual sampling sites where macaques were tested for infection with Treponema spp. during 1999–2012 and the number of human yaws cases during 2001–2011, Sulawesi, Indonesia. Numbers in parentheses indicate number nonhuman primates sampled in each of the 6 provinces. ESPLINE TP (Fujirebio Inc., Tokyo, Japan) reagent for the detection of T. pallidum antibodies was used to determine whether macaque samples were positive for treponemal infection. The number of human yaws cases was determined by the World Health Organization (1). Inset map shows the location of Sulawesi in Indonesia (gray shading). NA, not available.

Main Article

References
  1. The World Health Organization. Eradication of yaws—the Morges strategy. Wkly Epidemiol Rec. 2012;87:189–94.PubMedGoogle Scholar
  2. Knauf  S, Liu  H, Harper  KN. Treponemal infection in nonhuman primates as possible reservoir for human yaws. Emerg Infect Dis. 2013;19:2058–60. DOIPubMedGoogle Scholar
  3. Marks  M, Mitjà  O, Vestergaard  LS, Pillay  A, Knauf  S, Chen  CY, et al. Challenges and key research questions for yaws eradication. Lancet Infect Dis. 2015;15:1220–5. DOIPubMedGoogle Scholar
  4. Zobaníková  M, Strouhal  M, Mikalová  L, Cejková  D, Ambrožová  L, Pospíšilová  P, et al. Whole genome sequence of the Treponema Fribourg-Blanc: unspecified simian isolate is highly similar to the yaws subspecies. PLoS Negl Trop Dis. 2013;7:e2172. DOIPubMedGoogle Scholar
  5. Smith  JL, David  NJ, Indgin  S, Israel  CW, Levine  BM, Justice  J Jr, et al. Neuro-ophthalmological study of late yaws and pinta. II. The Caracas project. Br J Vener Dis. 1971;47:226–51.PubMedGoogle Scholar
  6. Nichols  HJ. Experimental yaws in the monkey and rabbit. J Exp Med. 1910;12:616–22. DOIPubMedGoogle Scholar
  7. Lahariya  C, Pradhan  SK. Can Southeast Asia eradicate yaws by 2010? Some lessons from the Yaws Eradication Programme of India. Natl Med J India. 2007;20:81–6.PubMedGoogle Scholar
  8. Mitjà  O, Marks  M, Konan  DJ, Ayelo  G, Gonzalez-Beiras  C, Boua  B, et al. Global epidemiology of yaws: a systematic review. Lancet Glob Health. 2015;3:e324–31. DOIPubMedGoogle Scholar
  9. Hotez  PJ, Bottazzi  ME, Strych  U, Chang  LY, Lim  YAL, Goodenow  MM, et al. Neglected tropical diseases among the Association of Southeast Asian Nations (ASEAN): overview and update. PLoS Negl Trop Dis. 2015;9:e0003575. DOIPubMedGoogle Scholar
  10. Jones-Engel  L, Steinkraus  KA, Murray  SM, Engel  GA, Grant  R, Aggimarangsee  N, et al. Sensitive assays for simian foamy viruses reveal a high prevalence of infection in commensal, free-ranging Asian monkeys. J Virol. 2007;81:7330–7. DOIPubMedGoogle Scholar
  11. Knauf  S, Dahlmann  F, Batamuzi  EK, Frischmann  S, Liu  H. Validation of serological tests for the detection of antibodies against Treponema pallidum in nonhuman primates. PLoS Negl Trop Dis. 2015;9:e0003637. DOIPubMedGoogle Scholar
  12. Jones-Engel  L, Engel  GA, Schillaci  MA, Babo  R, Froehlich  J. Detection of antibodies to selected human pathogens among wild and pet macaques (Macaca tonkeana) in Sulawesi, Indonesia. Am J Primatol. 2001;54:171–8. DOIPubMedGoogle Scholar
  13. Wilbur  AK, Engel  GA, Rompis  A, A Putra  IG, Lee  BP, Aggimarangsee  N, et al. From the mouths of monkeys: detection of Mycobacterium tuberculosis complex DNA from buccal swabs of synanthropic macaques. Am J Primatol. 2012;74:676–86. DOIPubMedGoogle Scholar
  14. Oberste  MS, Feeroz  MM, Maher  K, Nix  WA, Engel  GA, Hasan  KM, et al. Characterizing the picornavirus landscape among synanthropic nonhuman primates in Bangladesh, 2007 to 2008. J Virol. 2013;87:558–71. DOIPubMedGoogle Scholar
  15. Karlsson  EA, Small  CT, Freiden  P, Feeroz  MM, Matsen  FA IV, San  S, et al. Non-human primates harbor diverse mammalian and avian astroviruses including those associated with human infections. PLoS Pathog. 2015;11:e1005225. DOIPubMedGoogle Scholar

Main Article

Page created: April 17, 2017
Page updated: April 17, 2017
Page reviewed: April 17, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external