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Volume 23, Number 6—June 2017

Seoul Virus Infection in Humans, France, 2014–2016

Jean-Marc ReynesComments to Author , Damien Carli, Jean-Baptiste Bour, Samir Boudjeltia, Anny Dewilde, Guillaume Gerbier, Timothée Nussbaumer, Véronique Jacomo, Marie-Pierre Rapt, Pierre E. Rollin, and Alexandra Septfons
Author affiliations: Institut Pasteur, Lyon, France (J.-M. Reynes, D. Carli); Centre Hospitalier Universitaire Dijon-Bourgogne, Dijon, France (J.-B. Bour, S. Boudjeltia); Centre Hospitalier Universitaire Lille, Lille, France (A. Dewilde); Direction Départementale de la Cohésion Sociale et de la Protection des Populations, Colmar, France (G. Gerbier); Hôpitaux Civils de Colmar, Colmar (T. Nussbaumer); Biomnis, Lyon (V. Jacomo); Centre Hospitalier, Bar-le-Duc, France (M.-P. Rapt); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (P.E. Rollin); Santé Publique France, Saint-Maurice, France (A. Septfons)

Main Article

Table 1

Characteristics of 3 patients infected with Seoul virus, France, 2014–2016*

Characteristic† Patient 1 Patient 2 Patient 3
Signs and symptoms
Fever Yes Yes Yes
Weakness Yes No Yes
Headache Yes Yes Yes
Muscle or join pain No No Yes
Chest pain No No Yes
Abdominal pain No No Yes
Nausea Yes No Yes
Vomiting Yes No Yes
Anorexia No No Yes
Cough Yes No No
Dyspnea No No Yes
Anuria No No Yes
Laboratory results (reference range or value)
Leukocytes, × 109 cells/L (4.0–10.0 × 109 cells/L) Reference Reference e D6: 19.4
Platelets, × 109/L (150–450 × 109/L) D4: 52 D4: 59 D4: 21
Hemoglobin, g/dL (13.0–17.0 g/dL) D6: 11.9 Reference e D13: 9.8
C-reactive protein, mg/L (<3.2 mg/L) D3: 82.0 D4: 26.0 D4: 155.0
LDH, IU/L (120–228 IU/L) D3: 999‡ NA D4: 876
AST, IU/L (15-37 IU/L) D3: 440 D5: 183 D4: 439
ALT, IU/L (21–72 IU/L) D9: 278 D5: 210 D4: 390
GGT, IU/L (15–85 IU/L) Reference D5: 87 D9: 722
Creatinine, mg/L (6–11 mg/L) D3: 16.4 Reference D8: 75.0
Microscopic hematuria NA No Yes
Proteinuria, g/24 h (<0.3 g/24 h) NA NA D8: 3.82

*ALT, alanine aminotransferase; AST, aspartate aminotransferase; D, day after symptom onset; GGT γ-glutamyl transferase; LDH, lactate dehydrogenase; NA, not available;
†Dysphagia, diarrhea, jaundice, sore throat, rash, bleeding manifestation, and loss of consciousness were not observed for these patients.
‡Patient 1 also had posttraumatic rhabdomyolysis: myoglobin level 869.5 μg/mL at D3 (reference range 16.0–116.0 µg/mL) and creatine kinase level 9,444 μg/mL at D5 (reference range 39–308 μg/mL).

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Page created: May 16, 2017
Page updated: May 16, 2017
Page reviewed: May 16, 2017
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