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Volume 23, Number 6—June 2017
CME ACTIVITY - Synopsis

Sporadic Creutzfeldt-Jakob Disease in 2 Plasma Product Recipients, United Kingdom

Patrick Urwin, Kumar Thanigaikumar, James W. Ironside, Anna Molesworth, Richard S. Knight, Patricia E. Hewitt, Charlotte Llewelyn, Jan Mackenzie, and Robert G. WillComments to Author 
Author affiliations: University of Edinburgh Western General Hospital, Edinburgh, Scotland, UK (P. Urwin, J.W. Ironside, A. Molesworth, R.S. Knight, J. Mackenzie, R.G. Will); University Hospital Lewisham, London, UK (K. Thanigaikumar); National Health Service Blood and Transplant, London (P.E. Hewitt); National Health Service Blood and Transplant/Public Health England Epidemiology Unit, Cambridge, UK (C. Llewelyn)

Main Article

Figure

Results of neuropathologic examinations of the brains of the 2 patients with sporadic Creutzfeldt-Jakob disease, United Kingdom, 2014. A) Microvacuolar spongiform change in the frontal cortex (case 1). Hematoxylin and eosin stain; original magnification ×400. B) Fine granular/synaptic accumulation of abnormal prion protein in the cerebral cortex (case 1). 12F10 antiprion protein antibody; original magnification ×400. C) Microvacuolar spongiform change with neuronal loss and gliosis in the fronta

Figure. Results of neuropathologic examinations of the brains of the 2 patients with sporadic Creutzfeldt-Jakob disease, United Kingdom, 2014. A) Microvacuolar spongiform change in the frontal cortex (case 1). Hematoxylin and eosin stain; original magnification ×400. B) Fine granular/synaptic accumulation of abnormal prion protein in the cerebral cortex (case 1). 12F10 antiprion protein antibody; original magnification ×400. C) Microvacuolar spongiform change with neuronal loss and gliosis in the frontal cortex (case 2). Hematoxylin and eosin stain; original magnification ×400. D) Focally intense granular/synaptic accumulation of abnormal prion protein in the cerebral cortex (case 2). 12F10 antiprion protein antibody; original magnification ×400.

Main Article

Page created: May 11, 2017
Page updated: May 11, 2017
Page reviewed: May 11, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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