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Volume 23, Number 6—June 2017
CME ACTIVITY - Synopsis

Sporadic Creutzfeldt-Jakob Disease in 2 Plasma Product Recipients, United Kingdom

Patrick Urwin, Kumar Thanigaikumar, James W. Ironside, Anna Molesworth, Richard S. Knight, Patricia E. Hewitt, Charlotte Llewelyn, Jan Mackenzie, and Robert G. WillComments to Author 
Author affiliations: University of Edinburgh Western General Hospital, Edinburgh, Scotland, UK (P. Urwin, J.W. Ironside, A. Molesworth, R.S. Knight, J. Mackenzie, R.G. Will); University Hospital Lewisham, London, UK (K. Thanigaikumar); National Health Service Blood and Transplant, London (P.E. Hewitt); National Health Service Blood and Transplant/Public Health England Epidemiology Unit, Cambridge, UK (C. Llewelyn)

Main Article

Table 2

Selected characteristics and clinical features of the 2 patients with sporadic Creutzfeldt-Jakob disease described in cases 1 and 2, United Kingdom, 2014*

Characteristic/clinical feature
Case 1
 Case 2
Patient age, y/sex
 64/F
 64/F
Symptoms/signs
 Ataxia, cognitive impairment, visual impairment, myoclonus
 Somnolence/depression, dysphasia, cognitive impairment, myoclonus/ataxia
Magnetic resonance imaging + +
Electroencephalogram + Slow activity
Cerebrospinal fluid 14–3–3 assay + +
RT-QuIC
+
 +
Genotype MM MM
Diagnosis Definite sCJD Definite sCJD
Duration 3 mo 7 mo

*RT-QuIC, real-time quaking-induced conversion; sCJD, sporadic Creutzfeldt-Jakob disease.

Main Article

Page created: May 11, 2017
Page updated: May 11, 2017
Page reviewed: May 11, 2017
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