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Volume 23, Number 7—July 2017
CME ACTIVITY - Research

Clonal Clusters and Virulence Factors of Group C and G Streptococcus Causing Severe Infections, Manitoba, Canada, 2012–2014

Sylvain A. LotherComments to Author , Walter Demczuk, Irene Martin, Michael R. Mulvey, Brenden Dufault, Philippe Lagacé-Wiens, and Yoav Keynan
Author affiliations: AuUniversity of Manitoba, Winnipeg, Manitoba, Canada (S. Lother, B. Dufault, P. Lagacé-Wiens, Y. Keynan); National Microbiology Laboratory, Winnipeg (W. Demczuk, I. Martin, M. Mulvey); Diagnostic Service Manitoba, Winnipeg (P. Lagacé-Wiens)

Main Article

Table 3

Distribution of virulence factor genes in blood and respiratory isolates of Streptococcus dysgalactiae subsp. equisimilis from patients with group C and G Streptococcus bacteremia causing severe infections, Winnipeg, Manitoba, Canada, 2012–2014

Gene Gene product No. isolates positive for virulence factor/no. tested (%)
 Reference
Total isolates Blood isolate Respiratory isolate
Adhesins
gapC Glyceraldehyde 3-P dehydrogenase 122/122 (100) 89/89 (100) 33/33 (100) (22)
Lmb Laminin-binding surface protein 122/122 (100) 89/89 (100) 33/33 (100) (22)
fnbB Fibronectin-binding protein 120/122 (98.4) 89/89 (100) 31/33 (94) (35)
fnB Fibronectin-binding protein 120/122 (98.4) 89/89 (100) 31/33 (94) (35)
cbp Collagen-binding protein 34/122 (27.9) 29/89 (33) 5/33 (15) (22)
gfbA Fibronectin-binding protein 32/122 (26.2) 24/89 (30) 8/33 (24) (35)
fbp Fibronectin-binding protein 11/122 (9.0) 10/89 (11) 1/33 (3) (22)
fbsA Fibrinogen-binding protein 0/122 0/89 0/33 (35)
pavA Adherence and virulence protein A 0/122 0/89 0/33 (35)
fnbA
 Fibronectin-binding protein
 0/122
 0/89
 0/33
 (35)
Antiphagocytosis
cba
 C protein β antigen
 0/122
 0/89
 0/33
 (35)
Complement protease
scpA C5a peptidase 122/122 (100) 89/89 (100) 33/33 (100) (22,35)
scpB
 C5a peptidase
 122/122 (100)
 89/89 (100)
 33/33 (100)
 (35)
Exoenzyme
hylB
 Hyaluronidase
 122/122 (100)
 89/89 (100)
 33/33 (100)
 (22,35)
Invasion
bca
 C protein α antigen
 11/122 (9.0)
 5/89 (6)
 6/33 (18)
 (35)
Streptokinases
ska Streptokinase 122/122 (100) 89/89 (100) 33/33 (100) (22)
skc Streptokinase 122/122 (100) 89/89 (100) 33/33 (100) (35)
skg
 Streptokinase
 122/122 (100)
 89/89 (100)
 33/33 (100)
 (35)
Toxins
sagA Streptolysin S 122/122 (100) 89/89 (100) 33/33 (100) (22)
slo Streptolysin O 122/122 (100) 89/89 (100) 33/33 (100) (22)
speG Streptococcus pyrogenic exotoxin G 81/122 (66.4) 58/89 (65) 23/33 (70) (22)
cylE β hemolysin/cytolysin 0/122 0/89 0/33 (35)
Cfb
 CAMP factor
 0/122
 0/89
 0/33
 (35)
Other
sicG Streptococcal inhibitor of a complement 47/122 (38.5) 35/89 (39) 12/33 (36) (22)

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Page updated: June 15, 2017
Page reviewed: June 15, 2017
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