Table 1

Clinical Laboratory Values as Early Indicators of Ebola Virus Infection in Nonhuman Primates

Ronald B. Reisler, Chenggang Yu, Michael J. Donofrio, Travis K. Warren, Jay B. Wells, Kelly S. Stuthman, Nicole L. Garza, Sean A. Vantongeren, Ginger C. Donnelly, Christopher D. Kane, Mark G. Kortepeter, Sina Bavari, and Anthony P. Cardile

Author affiliations: United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA

Main Article

Baseline characteristics and clinical data for 3 nonhuman primate models of lethal Ebola virus disease*

Variable	Models of infection
	Rhesus macaque with		p value†	Cynomolgus macaque with Kikwit strain, n = 6	p value‡
	Kikwit strain, n = 18	Makona strain, n = 6	p value†	Cynomolgus macaque with Kikwit strain, n = 6	p value‡
Baseline characteristic
Weight, kg	4.92	4.79	0.894	4.44	0.526
Age, y	3.94	3.49	0.575	4.92	0.107
Postchallenge clinical data
Survival time, h	186.9	337.5	0.005	175.2	0.739
Clinical responsiveness score, d§
3	0	0	None	0	None
5	0.56	0	0.078	0.55	0.729
7	1.64	0.17	0.004	2.60	0.059
Presence of petechial rash, d	5.65	8.17	<0.001	5.17	0.265
Decreased food consumption, d	5.11	8.33	<0.001	4.67	0.178
Presence of anuria, d	6.43	8.20	0.008	6.40	0.500

*Data are means.
†For rhesus macaque model with Ebola virus (EBOV) Kikwit strain vs. Makona strain. Bold indicates p<0.05.
‡For rhesus macaque model with EBOV Kikwit strain vs. cynomolgus macaque model with EBOV Kikwit strain.
§Clinical Responsiveness Score: 0 = active, 1 = decreased activity; 2 = mildly unresponsive (becomes active when approached), occasional prostration; 3 = moderate unresponsiveness (may require prodding to respond), weakness; 4 = moderate to severe unresponsiveness (requires prodding), moderate prostration; 5 = moribund, severe unresponsiveness, pronounced prostration.

Main Article

Page created: July 17, 2017

Page updated: July 17, 2017

Page reviewed: July 17, 2017

The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.