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Volume 23, Number 9—September 2017

Dispatch

Emergence of Plasmid-Mediated Fosfomycin-Resistance Genes among Escherichia coli Isolates, France

Yahia Benzerara, Salah Gallah, Baptiste Hommeril, Nathalie Genel, Dominique Decré, Martin Rottman, and Guillaume ArletComments to Author 
Author affiliations: Assistance Publique des Hôpitaux de Paris Hôpitaux Universitaires Est Parisiens Paris, France (Y. Benzerara, S. Gallah, B. Hommeril, D. Decré, G. Arlet); Université Pierre et Marie Curie, Sorbonne Université, Paris (N. Genel, D. Decré, G. Arlet); Assistance Publique des Hôpitaux de Paris Hôpitaux Universitaires Paris Ile de France Ouest, Hôpital Raymond Poincaré, Garches, France (M. Rottman); Université de Versailles Saint-Quentin-en-Yvelines, St-Quentin en Yvelines, France (M. Rottman)

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Figure

Inhibition of FosA-mediated fosfomycin resistance by phosphonoformiate. A modified Kirby-Bauer disk diffusion susceptibility assay was performed. In brief, a Mueller-Hinton agar plate was streaked with a 0.5 McFarland suspension of the isolate assayed. Three disks were placed on the agar: a 200-µg fosfomycin disk (upper left), a 100-µg phosphonoformiate disk (lower center), and a disk with both a 200-µg fosfomycin and 100-µg phosphonoformiate (upper right). The diameter of the growth inhibition

Figure. Inhibition of FosA-mediated fosfomycin resistance by phosphonoformiate. A modified Kirby-Bauer disk diffusion susceptibility assay was performed. In brief, a Mueller-Hinton agar plate was streaked with a 0.5 McFarland suspension of the isolate assayed. Three disks were placed on the agar: 200-µg fosfomycin disk (upper left), a 100-µg phosphonoformiate disk (lower center), and a disk with both a 200-µg fosfomycin and 100-µg phosphonoformiate (upper right). The diameter of the growth inhibition zone around each disk was measured after 18–24 h incubation at 35°C (+2°C). FosA-mediated fosfomycin resistance is inhibited by phosphonoformiate and is demonstrated by an increase in the diameter of the growth inhibition zone by >4 mm.

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