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Volume 24, Number 1—January 2018
Dispatch

Two-Center Evaluation of Disinfectant Efficacy against Ebola Virus in Clinical and Laboratory Matrices

Sophie J. Smither, Lin Eastaugh, Claire Marie Filone, Denise Freeburger, Artemas Herzog, M. Stephen Lever, David M. Miller, Dana Mitzel, James W. Noah, Mary S. Reddick-Elick, Amy Reese, Michael Schuit, Carly B. Wlazlowski, Michael Hevey, and Victoria Wahl-JensenComments to Author 
Author affiliations: Defence Science and Technology Laboratory, Porton Down, UK (S.J. Smither, L. Eastaugh, M.S. Lever); National Biodefense Analysis and Countermeasures Center, Frederick, Maryland, USA (C.M. Filone, D. Freeburger, D.M. Miller, D. Mitzel, J.W. Noah, M.S. Reddick-Elick, A. Reese, M. Schuit, C.B. Wlazlowski, M. Hevey, V. Wahl-Jensen); Censeo Consulting Group, Seattle, Washington, USA (A. Herzog)

Main Article

Figure 1

Effect of common bleach disinfection of Ebola virus in A) dried cell culture medium, B) wet blood, and C) dried blood. Coupons were spotted with Ebola virus/Makona (EBOV/Mak). Bleach solutions (0.5% or 1.0% hypochlorite) were effective in reducing the titer of EBOV/Mak to the assay LLOQ in dried cell culture medium or wet blood. Incomplete disinfection was observed when virus was suspended in blood and dried for 1 h before disinfection. Data were confirmed for dried cell culture medium and dried

Figure 1. Effect of common bleach disinfection of Ebola virus in A) dried cell culture medium, B) wet blood, and C) dried blood. Coupons were spotted with Ebola virus/Makona (EBOV/Mak). Bleach solutions (0.5% or 1.0% hypochlorite) were effective in reducing the titer of EBOV/Mak to the assay LLOQ in dried cell culture medium or wet blood. Incomplete disinfection was observed when virus was suspended in blood and dried for 1 h before disinfection. Data were confirmed for dried cell culture medium and dried blood studies at an independent laboratory (DSTL). Error bars indicate SD. *Significant difference (p<0.05) between control and disinfected samples. DSTL, Defence Science and Technology Laboratory; LLOQ, lower limit of quantification; NBACC, National Biodefense Analysis and Countermeasures Center.

Main Article

Page created: December 19, 2017
Page updated: December 19, 2017
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