Two-Center Evaluation of Disinfectant Efficacy against Ebola Virus in Clinical and Laboratory Matrices
Sophie J. Smither, Lin Eastaugh, Claire Marie Filone, Denise Freeburger, Artemas Herzog, M. Stephen Lever, David M. Miller, Dana Mitzel, James W. Noah, Mary S. Reddick-Elick, Amy Reese, Michael Schuit, Carly B. Wlazlowski, Michael Hevey, and Victoria Wahl-Jensen
Author affiliations: Defence Science and Technology Laboratory, Porton Down, UK (S.J. Smither, L. Eastaugh, M.S. Lever); National Biodefense Analysis and Countermeasures Center, Frederick, Maryland, USA (C.M. Filone, D. Freeburger, D.M. Miller, D. Mitzel, J.W. Noah, M.S. Reddick-Elick, A. Reese, M. Schuit, C.B. Wlazlowski, M. Hevey, V. Wahl-Jensen); Censeo Consulting Group, Seattle, Washington, USA (A. Herzog)
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Figure 2
Figure 2. Effect of 5% peracetic acid disinfection of Ebola virus in 3 different matrices. Coupons were spotted with Ebola virus/Makona (EBOV/Mak) in cell culture medium (A) or blood (B, C). Peracetic acid was effective in reducing the titer of EBOV/Mak to the assay LLOQ in dried cell culture medium or wet blood. Although complete disinfection was observed when virus was suspended in blood and dried for 1 h before disinfection with 5% peracetic acid (NBACC), incomplete disinfection was observed with 0.2% peracetic acid (DSTL). Error bars indicate SD. *Significant difference (p<0.05) between control and disinfected samples. DSTL, Defence Science and Technology Laboratory; LLOQ, lower limit of quantification; NBACC, National Biodefense Analysis and Countermeasures Center.
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