Volume 24, Number 2—February 2018
Research
Use of Pristinamycin for Macrolide-Resistant Mycoplasma genitalium Infection
Table 4
Proportions of Mycoplasma genitalium infections cured with and without silent mutations (no resulting amino acid change) in the L4 and L22 genes, Sexual Health Centre, Melbourne, Victoria, Australia, 2012–2016*
Mutation | No. cured/no. treated (%)† | Unadjusted odds ratio for cure (95% CI) | p value |
---|---|---|---|
L4 T327C | |||
Absent | 19/28 (68) | ||
Present |
2/5 (40) |
0.32 (0.23–3.39) |
0.23 |
L4 G429A | |||
Absent | 17/24 (71) | ||
Present |
4/9 (44) |
0.33 (0.05–2.12) |
0.16 |
L4 C438T ‡ | |||
Absent | 18/25 (72) | ||
Present |
3/8 (38) |
0.23 (0.030–1.65) |
0.08 |
L4 C468T | |||
Absent | 17/27 (63) | ||
Present |
4/6 (67) |
1.18 (0.14–15.2) |
0.86 |
L4 G507A‡ | |||
Absent | 18/25 (72) | ||
Present |
3/8 (38) |
0.23 (0.030–1.65) |
0.08 |
L4 C516T‡ | |||
Absent | 18/25 (72) | ||
Present |
3/8 (38) |
0.23 (0.030–1.65) |
0.08 |
L22 G81A K27 | |||
Absent | 18/26 (69) | ||
Present |
7/12 (58) |
0.62 (0.12–3.34) |
0.51 |
L22 C231T N77 | |||
Absent | 17/24 (71) | ||
Present |
8/14 (57) |
0.55 (0.11–2.73) |
0.39 |
L22 C351T L117 | |||
Absent | 23/34 (68) | ||
Present | 2/4 (50) | 0.48 (0.032–7.56) | 0.48 |
*M. genitalium numbering based on reference genome GenBank accession number L43967.2
†The L22 gene was sequenced in 38 infections and the L4 gene was sequenced in 33 infections.
‡These 3 mutations always occurred together.