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Volume 24, Number 2—February 2018
Research

Spread of Meropenem-Resistant Streptococcus pneumoniae Serotype 15A-ST63 Clone in Japan, 2012–2014

Satoshi NakanoComments to Author , Takao Fujisawa, Yutaka Ito, Bin Chang, Yasufumi Matsumura, Masaki Yamamoto, Miki Nagao, Shigeru Suga, Makoto Ohnishi, and Satoshi Ichiyama
Author affiliations: Kyoto University Graduate School of Medicine, Kyoto, Japan (S. Nakano, Y. Matsumura, M. Yamamoto, M. Nagao, S. Ichiyama); National Hospital Organization Mie National Hospital, Tsu, Japan (T. Fujisawa, S. Suga); Nagoya City University Graduate School of Medical Science, Nagoya, Japan (Y. Ito); National Institute of Infectious Diseases, Tokyo, Japan (B. Chang, M. Ohnishi)

Main Article

Figure 2

Genomic similarities to Streptococcus pneumoniae G54 (reference sequence GenBank accession no. NC_011072.11) and Japan meropenem-nonsusceptible serotype 15A-ST63 isolate-specific recombination sites that were obtained in Genealogies Unbiased By recomBinations In Nucleotide Sequences (28) by using all clade I and clade I-MNS isolates. Colored segments indicate >95% similarity; gray segments indicate >90% similarity by BLAST (27) comparison between each isolate genome and S. pneumoniae G54.

Figure 2. Genomic similarities to Streptococcus pneumoniae G54 (reference sequence GenBank accession no. NC_011072.11) and Japan meropenem-nonsusceptible serotype 15A-ST63 isolate-specific recombination sites that were obtained in Genealogies Unbiased By recomBinations In Nucleotide Sequences (28) by using all clade I and clade I-MNS isolates. Colored segments indicate >95% similarity; gray segments indicate >90% similarity by BLAST (27) comparison between each isolate genome and S. pneumoniae G54. The outside red bars indicate the recombination sites that were specific to meropenem-nonsusceptible serotype 15A-ST63 isolates and identified in all of these isolates. Red numbers indicate the sequence coordinates of the recombination sites when S. pneumoniae G54 was used. Outside short black lines indicate each penicillin binding protein region. MR, Japan meropenem nonsusceptible; MS, Japan meropenem susceptible; ST, sequence type.

Main Article

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Page created: January 17, 2018
Page updated: January 17, 2018
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