Volume 24, Number 3—March 2018
Research
Influenza Vaccination and Incident Tuberculosis among Elderly Persons, Taiwan1
Yung-Feng Yen2, Sheng-Wei Pan, Vincent Yi-Fong Su2, Pei-Hung Chuang, Jia-Yih Feng3
, and Wei-Juin Su3
, and Wei-Juin Su3
Table 2
Univariate and multivariate analyses of the protective and risk factors for incident TB among elderly persons with and without influenza vaccination, Taiwan, 2005–2012*
| Characteristic | Person-years | Incidence density† | Univariate analysis, HR (95% CI) | Multivariate analysis, adjusted HR (95% CI) |
|---|---|---|---|---|
| Influenza vaccination | ||||
| No | 227,910.5 | 175.5 | 1 | 1 |
| Yes |
510,458.1 |
145.2 |
0.83 (0.73–0.93)‡ |
0.82 (0.73–0.93)‡ |
| Age, y | ||||
| 65–69 | 293,257.6 | 106.4 | 1 | 1 |
| 70–74 | 197,971.8 | 150.5 | 1.41 (1.21–1.66)§ | 1.18 (1.00–1.38)¶ |
| >75 |
247,139.3 |
214.9 |
2.02 (1.75–2.32)§ |
1.43 (1.24–1.66)§ |
| Sex | ||||
| F | 385,893.5 | 62.7 | 1 | 1 |
| M |
352,475.2 |
255.1 |
4.07 (3.53–4.69)§ |
3.32 (2.88–3.84)§ |
| Income level | ||||
| Low | 507,842.5 | 170.9 | 1 | 1 |
| Intermediate | 133,417.7 | 122.9 | 0.72 (0.61–0.85)§ | 0.88 (0.74–1.04) |
| High |
97,108.5 |
112.2 |
0.66 (0.54–0.80)§ |
0.82 (0.67–1.00) |
| Urbanization | ||||
| Urban | 187049.0 | 129.4 | 1 | 1 |
| Suburban | 436275.1 | 157.9 | 1.22 (1.05–1.41)‡ | 1.13 (0.98–1.31) |
| Rural |
115044.5 |
182.5 |
1.41 (1.17–1.70)§ |
1.37 (1.13–1.65)¶ |
| Concurrent conditions | ||||
| Diabetes | ||||
| No | 596,098.4 | 153.5 | 1 | 1 |
| Yes | 142,270.2 | 158.9 | 1.03 (0.89–1.20) | 1.17 (1.02–1.33)¶ |
| CHF | ||||
| No | 708,633.3 | 152.4 | 1 | 1 |
| Yes | 29,735.4 | 205.1 | 1.34 (1.04–1.74)¶ | 1.37 (1.16–1.62)§ |
| COPD | ||||
| No | 621,742.5 | 133.3 | 1 | 1 |
| Yes | 116,626.2 | 267.5 | 2.00 (1.76–2.28)§ | 2.77 (2.43–3.15)§ |
| Asthma | ||||
| No | 676,539.1 | 145.9 | 1 | 1 |
| Yes | 61,829.5 | 249.1 | 1.71 (1.44–2.02)§ | 1.12 (0.96–1.30) |
| CVD | ||||
| No | 631659.3 | 152.0 | 1 | 1 |
| Yes | 106709.3 | 169.6 | 1.11 (0.95–1.31) | 0.89 (0.78–1.02) |
| HTN | ||||
| No | 360268.3 | 156.5 | 1 | 1 |
| Yes | 378100.3 | 152.6 | 0.97 (0.87–1.09) | 0.86 (0.76–0.98)¶ |
| CKD | ||||
| No | 693223.9 | 149.2 | 1 | 1 |
| Yes | 45144.7 | 237.0 | 1.59 (1.30–1.94)§ | 1.31 (1.12–1.53)§ |
| Cancer | ||||
| No | 696681.8 | 150.9 | 1 | 1 |
| Yes | 41686.8 | 215.9 | 1.43 (1.15–1.77)‡ | 1.96 (1.71–2.26)§ |
*CHF, congestive heart failure; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; CVD, cerebrovascular disease; HR, hazard ratio; HTN, hypertension; TB, tuberculosis.
†Per 100,000 person-years.
‡p<0.01.
§p<0.001.
¶p<0.05.
1The abstract of this study was presented at the 47th Union World Conference on Lung Health in Liverpool, United Kingdom, on October 27, 2016.
2These authors contributed equally to this article.
3These authors contributed equally to this article.
Page created: February 15, 2018
Page updated: February 15, 2018
Page reviewed: February 15, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
Content Credential