Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 24, Number 3—March 2018

Drug Resistance of Mycobacterium tuberculosis Complex in a Rural Setting, Angola

Ariadna Rando-Segura1, María Luisa Aznar1, María Milagros Moreno, Mateu Espasa, Elena Sulleiro, Cristina Bocanegra, Eva Gil, Arlete N.E. Eugénio, Carlos Escartin, Adriano Zacarias, Josep Vegue, Domingos Katimba, María Carmen Vivas, Estevao Gabriel, María Concepción Marina, Jacobo Mendioroz, María Teresa López, Tomas Pumarola, Israel Molina, and María Teresa TórtolaComments to Author 
Author affiliations: Vall d’Hebron University Hospital, PROSICS Barcelona, Universitat Autònoma de Barcelona, Barcelona, Spain (A. Rando-Segura, M.L. Aznar, M. Espasa, E. Sulleiro, C. Bocanegra, E. Gil, C. Escartin, J. Vegue, M.C. Vivas, M.C. Marina, J. Mendioroz, T. Pumarola, I. Molina, M.T. Tórtola); Hospital Nossa Senhora da Paz, Cubal, Angola (M.L. Aznar, M.M. Moreno, C. Bocanegra, E. Gil, A.N.E. Eugénio, A. Zacarias, D. Katimba, E. Gabriel, M.T. López)

Main Article

Table 2

Distribution of gene mutations associated with INH and RIF resistance, Cubal, Angola, April 2014–July 2015*

Phenotypic resistance
GenoType MTBDRplus
Isolates from new cases
Isolates from retreatment cases
INH, n = 113 47 66
∆wt, S315T1 23 42
∆wt 3 5
∆wt1, C15T 2 2
∆wt1 0 1
C15T 0 1

RIF, n = 81 20 61
1 3
Δwt2 0 2
Δwt2,3,4, D516V 1 8
Δwt3,4, D516V 3 3
Δwt4,5 0 1
Δwt7 0 1
Δwt7, H526Y 2 0
Δwt7, H526D 0 2
Δwt7,8, H526D 0 1
Δwt8 1 3
Δwt8, S531L 12 37

*INH, isoniazid; RIF, rifampin; –, no mutation inside region.

Main Article

1These authors were co-principal investigators for this article.

Page created: February 16, 2018
Page updated: February 16, 2018
Page reviewed: February 16, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.