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Volume 24, Number 3—March 2018

Characteristics Associated with Negative Interferon-γ Release Assay Results in Culture-Confirmed Tuberculosis Patients, Texas, USA, 2013–2015

Duc T. Nguyen, Larry D. Teeter, Julie Graves, and Edward A. GravissComments to Author 
Author affiliations: Houston Methodist Research Institute, Houston, Texas, USA (D.T. Nguyen, E.A. Graviss); Forensic Research and Analysis, Portland, Oregon, USA (L.D. Teeter); University of Medicine and Health Sciences, New York, New York, USA (J. Graves); University of Texas School of Public Health, Houston (J. Graves)

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Table 3

Multivariate analysis of association between negative IGRA results and culture-confirmed TB patient characteristics, by IGRA type, Texas, USA, 2013–2015*

All IGRA results, N = 1,338† QFT only, n = 875† T-SPOT.TB only, n = 463†
aOR (95% CI)
p value

aOR (95% CI)
p value

aOR (95% CI)
p value
Age in years 1.02 (1.01–1.03) <0.001 1.02 (1.01–1.04) <0.001 1.02 (1.00–1.03) 0.01
Non-Hispanic white race/ethnicity 2.61 (1.70–4.02) <0.001 2.76 (1.60–4.76) <0.001 2.29 (1.11–4.73) 0.03
HIV-positive status 2.72 (1.56–4.77) <0.001 3.59 (1.86–6.94) <0.001 1.34 (0.44–4.07) 0.60
Tested by T-SPOT.TB 1.58 (1.12–2.24) 0.01
Time from diagnosis to treatment 1.00 (1.00–1.01) 0.046 1.00 (1.00–1.01) 0.22 1.01 (1–1.01) 0.03

*aOR, adjusted odds ratio; IGRA, interferon-γ release assay; QFT, QuantiFERON-TB Gold In-Tube; TB, tuberculosis; –, analysis could not be performed.
†Multiple logistic models were run by using data from patients having complete data sets for all the included variables; aORs were from the multiple logistic regression models.

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Page created: February 15, 2018
Page updated: February 15, 2018
Page reviewed: February 15, 2018
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