Table 5

Characteristics Associated with Negative Interferon-γ Release Assay Results in Culture-Confirmed Tuberculosis Patients, Texas, USA, 2013–2015

Duc T. Nguyen, Larry D. Teeter, Julie Graves, and Edward A. Graviss

Author affiliations: Houston Methodist Research Institute, Houston, Texas, USA (D.T. Nguyen, E.A. Graviss); Forensic Research and Analysis, Portland, Oregon, USA (L.D. Teeter); University of Medicine and Health Sciences, New York, New York, USA (J. Graves); University of Texas School of Public Health, Houston (J. Graves)

Main Article

Cox proportional hazards model for association between 1-year survival from tuberculosis treatment start date and characteristics of culture-confirmed TB patients with negative IGRA results, by IGRA type, Texas, USA, 2013–2015*

Variable	All IGRA results, N = 1,343†		QFT only, n = 880†		T-SPOT.TB only, n = 463†
Variable	aHR (95% CI)	p value	aHR (95% CI)	p value	aHR (95% CI)	p value
Negative IGRA result	2.12 (1.24–3.63)	0.01	1.84 (0.98–3.47)	0.06	3.41 (1.18–9.88)	0.02
Age in years	1.06 (1.04–1.07)	<0.001	1.06 (1.04–1.07)	<0.001	1.05 (1.02–1.09)	0.002
Alcohol use	1.42 (0.82–2.48)	0.21	1.57 (0.85–2.93)	0.15	1.06 (0.30–3.80)	0.92
HIV positive	4.68 (2.40–9.12)	<0.001	4.60 (2.26–9.34)	<0.001	2.75 (0.32–23.40)	0.36
Time from diagnosis to treatment	0.99 (0.99–1.00)	0.002	0.99 (0.99–1.00)	0.01	0.99 (0.98–1.00)	0.10

*aHR, adjusted hazard ratio; IGRA, interferon-γ release assay; QFT, QuantiFERON-TB Gold In-Tube; TB, tuberculosis.
†Cox proportional hazards models were run with data from patients having complete data sets for all the included variables; aHRs were from the multivariate Cox proportional hazards models.

Main Article

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Page updated: February 15, 2018

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