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Volume 24, Number 4—April 2018

Artemisinin-Resistant Plasmodium falciparum with High Survival Rates, Uganda, 2014–2016

Mie Ikeda, Megumi Kaneko, Shin-Ichiro Tachibana, Betty Balikagala, Miki Sakurai-Yatsushiro, Shouki Yatsushiro, Nobuyuki Takahashi, Masato Yamauchi, Makoto Sekihara, Muneaki Hashimoto1, Osbert T. Katuro2, Alex Olia3, Paul S. Obwoya, Mary A. Auma, Denis A. Anywar, Emmanuel I. Odongo-Aginya, Joseph Okello-Onen4, Makoto Hirai, Jun Ohashi, Nirianne M.Q. Palacpac, Masatoshi Kataoka, Takafumi Tsuboi, Eisaku Kimura, Toshihiro Horii, and Toshihiro MitaComments to Author 
Author affiliations: Juntendo University School of Medicine, Tokyo, Japan (M. Ikeda, M. Kaneko, S.-I. Tachibana, M. Yamauchi, M. Sekihara, M. Hashimoto, M. Hirai, T. Mita); Ehime University, Matsuyama, Japan (B. Balikagala, T. Tsuboi); Tokyo Women’s Medical University, Tokyo (M. Sakurai-Yatsushiro, N. Takahashi); National Institute of Advanced Industrial Science and Technology, Kagawa, Japan (S. Yatsushiro, M. Kataoka); Med Biotech Laboratories, Kampala, Uganda (O.T. Katuro); Gulu University, Gulu, Uganda (A. Olia, D.A. Anywar, E.I. Odongo-Aginya, J. Okello-Onen); St. Mary’s Hospital Lacor, Gulu (P.S. Obwoya, M.A. Auma); The University of Tokyo, Tokyo (J. Ohashi); Osaka University, Osaka, Japan (N.M.Q. Palacpac, E. Kimura, T. Horii)

Main Article

Table 2

Characteristics of Plasmodium falciparum isolates with high ex vivo ring-stage survival rates and patients enrolled in study of Plasmodium falciparum survival rates, Uganda, 2014–2016*

Sample name Patient age, y Patient sex Signs and symptoms Day 0 parasitemia, % Early ring-stage parasites at day 0, % Mean parasite survival rate, %, ± SEM
H1 3.0 M Fever, headache, cough 0.85 80.4 34.3
H2 2.0 M Fever 15.0 98.2 13.3 ± 1.5
H3 3.2 M Fever 0.76 51.9 18.9 ± 0.9
H4 4.5 F Fever 2.56 72.0 18.1 ± 1.4
3D7 NA NA NA NA NA 0 ± 0
MRA-1236 NA NA NA NA NA 14.3 ± 0.5
MRA-1240 NA NA NA NA NA 27.0 ± 2.7

*Survival rate, parasitemia at 700 nmol/L dihydroartemisinin exposed/parasitemia at 0 nmol/L control × 100; mean value ± SEM in 2 (H2, H3, and H4) and 3 (3D7, MRA-1236, and MRA-1240) independent trials. Day 0, day of enrollment. NA, not applicable.

Main Article

1Current affiliation: National Institute of Advanced Industrial Science and Technology, Kagawa, Japan.

2Current affiliation: Mildmay Uganda-KAMPALA, Kampala, Uganda.

3Current affiliation: Gunma University, Gunma, Japan.


Page created: March 16, 2018
Page updated: March 16, 2018
Page reviewed: March 16, 2018
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